Reactome | NGF [extracellular region]

NGF [extracellular region]

Stable Identifier

R-DRE-167034

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

A0A2R8QCU0

Locations in the PathwayBrowser

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Signal Transduction (Danio rerio)

- Death Receptor Signalling (Danio rerio)
  - p75 NTR receptor-mediated signalling (Danio rerio)
    - Cell death signalling via NRAGE, NRIF and NADE (Danio rerio)
      - NRIF signals cell death from the nucleus (Danio rerio)
        
        TRAF6 binds to p75NTR:NRIF (Danio rerio)
        
        NGF ligand:p75NTR:NRIF [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:NRIF [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Danio rerio)
        
        NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:NRIF [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
    - NFG and proNGF binds to p75NTR (Danio rerio)
      - NGF homodimer binds to p75NTR (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
    - p75NTR regulates axonogenesis (Danio rerio)
      - Axonal growth stimulation (Danio rerio)
        
        NGF binding to p75NTR inactivates RHOA (Danio rerio)
        
        RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
    - p75NTR signals via NF-kB (Danio rerio)
      - NF-kB is activated and signals survival (Danio rerio)
        
        IKKbeta is activated (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
      - p75NTR recruits signalling complexes (Danio rerio)
        
        IKK-beta is recruited (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        IRAK interacts with TRAF6 (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        MYD88 dissociates (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        TRAF6 is auto-ubiquitinated (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        p62 is recruited and forms a complex with TRAF6 (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        p62 recruits an atypical PKC (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Danio rerio)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        p75NTR interacts with RIP2 (Danio rerio)
        
        NGF:p75NTR:RIP2 [plasma membrane] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by NTRKs (Danio rerio)
    - Expression and Processing of Neurotrophins (Danio rerio)
      - NGF processing (Danio rerio)
        
        Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
    - Signaling by NTRK1 (TRKA) (Danio rerio)
      - Activation of TRKA receptors (Danio rerio)
        
        TRKA activation by NGF (Danio rerio)
        
        Activated TrkA receptor internalizes to endosomes (Danio rerio)
        
        Activated TrkA receptor complex [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        The bound receptor dimerizes (Danio rerio)
        
        beta-NGF dimer:TrkA receptor [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Danio rerio)
        
        beta-NGF dimer:TrkA receptor [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        beta-NGF dimer binds to TrkA receptor (Danio rerio)
        
        beta-NGF dimer:TrkA receptor [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
      - PI3K/AKT activation (Danio rerio)
        
        Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)
        
        Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
        
        Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
      - Retrograde neurotrophin signalling (Danio rerio)
        
        Axonal transport of NGF:Trk complexes (Danio rerio)
        
        Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Danio rerio)
        
        Activated TrkA receptor complex [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
      - Signalling to ERKs (Danio rerio)
        
        Prolonged ERK activation events (Danio rerio)
        
        ARMS-mediated activation (Danio rerio)
        
        ARMS is phosphorylated by active TrkA receptor (Danio rerio)
        
        Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Danio rerio)
        
        Activated TrkA receptor complex [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Danio rerio)
        
        Activated TrkA receptor complex [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        C3G stimulates nucleotide exchange on Rap1 (Danio rerio)
        
        Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Danio rerio)
        
        Activated TrkA receptor complex [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)
        
        Crk's SH3 domain engages C3G (Danio rerio)
        
        Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Danio rerio)
        
        Activated TrkA receptor complex [plasma membrane] (Danio rerio)
        
        mature beta-NGF homodimer [extracellular region] (Danio rerio)
        
        Homologues of NGF [extracellular region] (Danio rerio)
        
        NGF [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A2R8QCU0

Reference Genes

ENSEMBL:ENSDARG00000111033

Other Identifiers

13282790

13284254

A_15_P632371

CJ006273

CJ006278

CJ009334

CJ009339

DRER32475

ENSDART00000103376

GO:0003674

GO:0005102

GO:0007165

GO:0008083

GO:0008150

JP006671

JP006676

JP009732

JP009737

NM_199210

Participant Of

hasMember

Homologues of NGF [extracellular region]

Other forms of this molecule

NGF [Golgi lumen]

NGF(19-241) [extracellular region]

NGF(19-241) [Golgi lumen]

NGF [cytosol]

Inferred From

NGF [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSDARP00000149525, ENSDART00000191260, ENSDARG00000111033

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