Reactome | LCK [cytosol]

LCK [cytosol]

Stable Identifier

R-DRE-167609

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

Q1RLY5

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Regulation of T cell activation by CD28 family (Danio rerio)
    - Co-stimulation by CD28 (Danio rerio)
      - CD28 dependent PI3K/Akt signaling (Danio rerio)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        CD28:PI3K [plasma membrane] (Danio rerio)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Danio rerio)
        
        FYN,LCK [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Intracellular signaling by second messengers (Danio rerio)
  - PIP3 activates AKT signaling (Danio rerio)
    - Negative regulation of the PI3K/AKT network (Danio rerio)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
        
        PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        Activator:PI3K [plasma membrane] (Danio rerio)
        
        CD28:PI3K [plasma membrane] (Danio rerio)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Danio rerio)
        
        FYN,LCK [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
      - Activator:PI3K [plasma membrane] (Danio rerio)
        
        CD28:PI3K [plasma membrane] (Danio rerio)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Danio rerio)
        
        FYN,LCK [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by SCF-KIT (Danio rerio)
    - Dimerization of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Disassociation and translocation of STATs to the nucleus (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Indirect recruitment of GAB2 to p-KIT (Danio rerio)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - JAK2 binds to p-KIT (Danio rerio)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Phosphorylation of GAB2 by SFKs (Danio rerio)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Phosphorylation of JAK2 (Danio rerio)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Phosphorylation of SHP2 by SFKs (Danio rerio)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Phosphorylation of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Recruitment of STATs (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Regulation of KIT signaling (Danio rerio)
      - Interaction of APS and p-KIT (Danio rerio)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - Phosphorylation of APS (Danio rerio)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
      - Recruitment of CBL to KIT (Danio rerio)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
    - Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
        
        SFKs:p-KIT complex [plasma membrane] (Danio rerio)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase cycle (Danio rerio)
      - RHOH GTPase cycle (Danio rerio)
        
        RHOH binds effectors at the plasma membrane (Danio rerio)
        
        RHOH effectors [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)
        
        RHOH:GTP:RHOH effectors [plasma membrane] (Danio rerio)
        
        RHOH effectors [cytosol] (Danio rerio)
        
        LCK [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q1RLY5

Reference Genes

BioGPS Gene:414333

ENSEMBL:ENSDARG00000102525

Monarch:414333

NCBI Gene:414333

UCSC:Q1RLY5

Reference Transcript

RefSeq:NM_001040328.1

Other Identifiers

13045844

13052160

414333

A_15_P283641

A_15_P668361

CJ002647

CJ002648

CJ002649

CJ008457

CJ008458

CJ008459

CJ008460

CJ009966

CJ009967

CJ009968

CJ009969

CJ010554

CJ010555

CJ010556

CJ010557

CJ011223

CJ011224

CJ011226

CJ012536

CJ012644

CJ013241

CJ013285

CJ013314

CJ013369

CJ013401

CJ013412

CJ014032

CJ014115

CUST_2647_PI428451953

CUST_2648_PI428451953

CUST_2649_PI428451953

CUST_2683_PI428451953

CUST_9380_PI428451958

DRER12297

DRER17089

DRER27573

DRER46966

ENSDART00000082356

ENSDART00000082356_1

ENSDART00000082356_2

ENSDART00000114706

GO:0003824

GO:0004672

GO:0004713

GO:0005515

GO:0005524

GO:0006468

GO:0016740

GO:0140096

GT_Xhyb_NM_001001596.1_384445

GT_Xhyb_XM_005158507.1_155076

GT_Xhyb_XM_005158561.1_124446

JP002836

JP002837

JP002838

JP008855

JP008856

JP008857

JP008858

JP010364

JP010365

JP010366

JP010367

JP010952

JP010953

JP010954

JP010955

MADDr01003808

NM_001001596

NM_001040328

Participates

as a member of

Inferred From

LCK [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001035418.1

ENSEMBL

ENSDARP00000131919, ENSDARP00000155237, ENSDARG00000115304, ENSDARG00000102525, ENSDART00000193178, ENSDART00000162306, ENSDART00000165282, ENSDARP00000130859

ZFIN

ZDB-GENE-040617-1

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