Reactome | fgb [extracellular region]

fgb [extracellular region]

Stable Identifier

R-DRE-140584

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

FGB, Q6NYE1

Locations in the PathwayBrowser

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Hemostasis (Danio rerio)

- Coagulation pathway (Danio rerio)
  - Fibrin formation (Danio rerio)
    - Adhesion of integrin αIIbβ3 to fibrin network (Danio rerio)
      - fibrin multimer [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)
      - fibrin multimer [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Danio rerio)
      - fibrin multimer [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Danio rerio)
      - fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - n fibrin monomers -> fibrin multimer (Danio rerio)
      - fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - fibrin multimer [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
- Platelet activation, signaling and aggregation (Danio rerio)
  - Platelet Aggregation (Plug Formation) (Danio rerio)
    - Integrin signaling (Danio rerio)
      - Autophosphorylation of PTK2 at Y397 (Danio rerio)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - Autophosphorylation of SRC (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Danio rerio)
        
        Interaction of SOS with GRB2 bound to FADK1 (Danio rerio)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Danio rerio)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Recruitment of GRB2 to p-PTK2 (Danio rerio)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - Phosphorylation of pPTK2 by SRC (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - Release of CSK from SRC (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - SYK activation by SRC (Danio rerio)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - SYK binds to integrin alphaIIb beta3 (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)

Signal Transduction (Danio rerio)

- Integrin signaling (Danio rerio)
  - Autophosphorylation of PTK2 at Y397 (Danio rerio)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Danio rerio)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - Autophosphorylation of SRC (Danio rerio)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
    - Focal complex [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Danio rerio)
    - Interaction of SOS with GRB2 bound to FADK1 (Danio rerio)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Danio rerio)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Recruitment of GRB2 to p-PTK2 (Danio rerio)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
    - Focal complex [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
      - fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - Phosphorylation of pPTK2 by SRC (Danio rerio)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Danio rerio)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Danio rerio)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - Release of CSK from SRC (Danio rerio)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - SYK activation by SRC (Danio rerio)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Danio rerio)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Danio rerio)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
  - SYK binds to integrin alphaIIb beta3 (Danio rerio)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Danio rerio)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
- MAPK family signaling cascades (Danio rerio)
  - MAPK1/MAPK3 signaling (Danio rerio)
    - RAF/MAP kinase cascade (Danio rerio)
      - MAP2K and MAPK activation (Danio rerio)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        MAP2Ks phosphorylate MAPKs (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        RAF phosphorylates MAP2K dimer (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
        
        Focal complex [plasma membrane] (Danio rerio)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Danio rerio)
        
        fibrin monomer [extracellular region] (Danio rerio)
        
        fgb [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6NYE1

Gene Names

fgb

Reference Genes

BioGPS Gene:337315 fgb

ENSEMBL:ENSDARG00000008969

KEGG:dre:337315 fgb

Monarch:337315 fgb

NCBI Gene:337315 fgb

UCSC:Q6NYE1 fgb

Reference Transcript

RefSeq:NM_212774.1 fgb

Other Identifiers

12945319

337315

A_15_P101786

A_15_P103556

A_15_P108310

A_15_P112538

A_15_P120602

A_15_P219251

CUST_12430_PI428451953

DRER01365

DRER33009

DRER34237

DRER38316

DRER43226

Dr.5462.1.S1_at

ENSDART00000011701

ENSDART00000011701_1

ENSDART00000011701_2

ENSDART00000041987

GO:0005102

GO:0005577

GO:0007596

GO:0030168

GO:0051258

LOLS11920

MADDr01007746

TC247603

XM_678919

XM_702216

Participates

as a component of

fibrin monomer [extracellular region] (Danio rerio)

Other forms of this molecule

fgb [platelet alpha granule lumen]

fgb [extracellular region]

fgb [plasma membrane]

fgb [extracellular region]

Inferred From

FGB [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSDART00000011701, ENSDARP00000016228, ENSDARG00000008969

ZFIN

ZDB-GENE-030131-9261

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