Reactome | CALM1 [nucleoplasm]

CALM1 [nucleoplasm]

Stable Identifier

R-DME-9016871

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

P47947

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Innate Immune System (Drosophila melanogaster)
  - C-type lectin receptors (CLRs) (Drosophila melanogaster)
    - CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
      - CLEC7A (Dectin-1) induces NFAT activation (Drosophila melanogaster)
        
        Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)
        
        NFAT:CaN:CaM [nucleoplasm] (Drosophila melanogaster)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Drosophila melanogaster)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)
  - Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
    - FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
      - Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)
        
        NFAT:CaN:CaM [nucleoplasm] (Drosophila melanogaster)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Drosophila melanogaster)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)

Neuronal System (Drosophila melanogaster)

- Transmission across Chemical Synapses (Drosophila melanogaster)
  - Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
    - Activation of NMDA receptors and postsynaptic events (Drosophila melanogaster)
      - Post NMDA receptor activation events (Drosophila melanogaster)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Drosophila melanogaster)
        
        CAMK4 autophosphorylates (Drosophila melanogaster)
        
        p-S12.S13,T200-CAMK4:CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - DAG and IP3 signaling (Drosophila melanogaster)
    - CaM pathway (Drosophila melanogaster)
      - Calmodulin induced events (Drosophila melanogaster)
        
        CaMK IV-mediated phosphorylation of CREB (Drosophila melanogaster)
        
        CAMK4 autophosphorylates (Drosophila melanogaster)
        
        p-S12.S13,T200-CAMK4:CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)
- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Opioid Signalling (Drosophila melanogaster)
        
        G-protein mediated events (Drosophila melanogaster)
        
        PLC beta mediated events (Drosophila melanogaster)
        
        Ca-dependent events (Drosophila melanogaster)
        
        CaM pathway (Drosophila melanogaster)
        
        Calmodulin induced events (Drosophila melanogaster)
        
        CaMK IV-mediated phosphorylation of CREB (Drosophila melanogaster)
        
        CAMK4 autophosphorylates (Drosophila melanogaster)
        
        p-S12.S13,T200-CAMK4:CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        p-T200-CAMK4:CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)
- Signaling by WNT (Drosophila melanogaster)
  - Beta-catenin independent WNT signaling (Drosophila melanogaster)
    - Ca2+ pathway (Drosophila melanogaster)
      - Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)
        
        NFATC1:CaN:CaM [nucleoplasm] (Drosophila melanogaster)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Drosophila melanogaster)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Drosophila melanogaster)
        
        CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)
        
        CALM1 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P47947

Reference Genes

BioGPS Gene:35473

CTD Gene:35473

ENSEMBL:FBgn0013348

FlyBase:FBgn0013348

KEGG:dme:Dmel_CG2981

Monarch:35473

NCBI Gene:35473

UCSC:P47947

Reference Transcript

Other Identifiers

143709_at

1625752_at

35473

GO:0005509

GO:0005737

GO:0005813

GO:0005815

GO:0030234

GO:0046872

Participates

as a member of

Homologues of CALM1 [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

Me3K116-CALM1 [cytosol]

CALM1 [extracellular region]

CALM1 [plasma membrane]

CALM1 [cytosol]

Inferred From

CALM1 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

FBpp0085438, FBpp0301709, FBgn0013348, FBtr0086102, FBtr0310003

FlyBase

FBgn0013348

PRO

P47947

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