Reactome | Tret1-1 [clathrin-coated endocytic vesicle membrane]

Tret1-1 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DME-8869111

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SLC2A8, A1Z8N1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Tret1-1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:A1Z8N1

Gene Names

Tret1-1

Reference Genes

BioGPS Gene:36248 Tret1-1

CTD Gene:36248 Tret1-1

ENSEMBL:FBgn0050035

Flybase:FBgn0050035

KEGG Gene (Drosophila melanogaster):Dmel_CG30035 Tret1-1

Monarch:36248 Tret1-1

NCBI Gene:36248 Tret1-1

UCSC:A1Z8N1 Tret1-1

Reference Transcript

Other Identifiers

147027_at

147028_i_at

147029_s_at

1627582_a_at

36248

GO:0003674

GO:0005351

GO:0005575

GO:0005886

GO:0005887

GO:0006810

GO:0008150

GO:0008643

GO:0015574

GO:0015771

GO:0016020

GO:0016021

GO:0022857

GO:0055085

Participant Of

hasMember

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

Tret1-1 [plasma membrane]

Inferred From

SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_725068.1, NP_610693.1

Flybase

FBgn0050035

PRO

A1Z8N1

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