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SLC2A8 [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-8869111
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
GLUT8, Solute carrier family 2, facilitated glucose transporter member 8, GTR8_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SLC2A8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NY64 SLC2A8
Gene Names
SLC2A8, GLUT8, GLUTX1
Chain
chain:1-477
Reference Genes
BioGPS Gene:29988 SLC2A8
COSMIC (genes):SLC2A8 SLC2A8
CTD Gene:29988 SLC2A8
dbSNP Gene:29988 SLC2A8
ENSEMBL:ENSG00000136856 SLC2A8
HGNC:13812 SLC2A8
KEGG:hsa:29988 SLC2A8
Monarch:29988 SLC2A8
NCBI Gene:29988 SLC2A8
OMIM:605245 SLC2A8
UCSC:Q9NY64 SLC2A8
Reference Transcript
RefSeq:NM_001271711.1 SLC2A8
RefSeq:NM_001271712.1 SLC2A8
RefSeq:NM_014580.4 SLC2A8
Other Identifiers
11743462_a_at
17089291
218985_PM_at
218985_at
29988
3189801
3189802
3189803
3189804
3189805
3189807
3189808
3189809
3189811
3189812
3189813
3189814
3189815
3189816
3189817
3189818
3189819
3189820
3189821
3189822
3189823
3189824
3189825
3189826
3189827
3189828
3189829
3189830
42601_at
48054_at
8158009
A_14_P136247
A_23_P252783
A_24_P175435
A_24_P64182
A_33_P3418158
GE55291
GE694418
GO:0001666
GO:0005215
GO:0005353
GO:0005355
GO:0005536
GO:0005765
GO:0005886
GO:0005975
GO:0008286
GO:0008645
GO:0015755
GO:0016020
GO:0022857
GO:0030659
GO:0030669
GO:0031410
GO:0033300
GO:0043226
GO:0055056
GO:0055085
GO:0070837
GO:1904659
HMNXSV003050071
ILMN_1724609
PH_hs_0022862
PH_hs_0032019
TC09000664.hg
g7657680_3p_at
Participates
as a member of
AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
SLC2A8 [plasma membrane]
Inferred To
nebu [clathrin-coated endocytic vesicle membrane]
(Drosophila melanogaster)
SLC2A8 [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
SLC2A8 [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
SLC2A8 [clathrin-coated endocytic vesicle membrane]
(Gallus gallus)
SLC2A8 [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
SLC2A8 [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
SLC2A8 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
885
ENSEMBL
ENSP00000362469
,
ENST00000373371
OpenTargets
ENSG00000136856
HPA
ENSG00000136856-SLC2A8
PRO
Q9NY64
Pharos - Targets
Q9NY64
GlyGen
Q9NY64
HMDB Protein
HMDBP11769
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