Reactome | Ubc4 [cytosol]

Ubc4 [cytosol]

Stable Identifier

R-DME-8864200

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

Ub-C92-UBE2K, P52486

Locations in the PathwayBrowser

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Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Protein ubiquitination (Drosophila melanogaster)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Drosophila melanogaster)
      - UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)
        
        Ub:E2 (UBA1 substrate) [cytosol] (Drosophila melanogaster)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Drosophila melanogaster)
        
        Ubc4 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P52486

Gene Names

Ubc4

Reference Genes

BioGPS Gene:39133 Ubc4

CTD Gene:39133 Ubc4

ENSEMBL:FBgn0015321

FlyBase:FBgn0015321

KEGG:dme:Dmel_CG8284 Ubc4

Monarch:39133 Ubc4

NCBI Gene:39133 Ubc4

UCSC:P52486 Ubc4

Reference Transcript

Other Identifiers

154399_at

1628595_at

39133

GO:0000166

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0016567

GO:0016740

GO:0016746

GO:0031625

GO:0061059

GO:0061631

GO:0070628

GO:0140096

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Ubc4 [cytosol]

Inferred From

Ub-C92-UBE2K [cytosol] (Homo sapiens)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 92 (in Homo sapiens)

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001287013.1, NP_001287014.1, NP_524010.2

ENSEMBL

FBtr0076395, FBpp0076124, FBgn0015321, FBtr0345603, FBpp0311673, FBpp0311672, FBtr0345604

FlyBase

FBgn0015321

PRO

P52486

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55035 Rpn10	3	PROS54 [nucleoplasm] (R-DME-216153) PROS54 [cytosol] (R-DME-205708) Rpn10 [cytosol] (R-DME-68800)	0.508	2
UniProt:P21461	2	SIAH2 [cytosol] (R-DME-374566) SIAH1 [cytosol] (R-DME-374563)	0.488	2
UniProt:Q7KNM2	6	lwr [nucleoplasm] (R-DME-912481) lwr [nucleoplasm] (R-DME-3730619) lwr [cytosol] (R-DME-4655342) lwr [cytosol] (R-DME-4656944) lwr [nucleoplasm] (R-DME-3730629) lwr [nuclear envelope] (R-DME-4655408)	0.488	2

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