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drk [cytosol]
Stable Identifier
R-DME-74686
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
GRB2-1, Q08012
Locations in the PathwayBrowser for interactor UniProt:P26675 Sos
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Hemostasis (Drosophila melanogaster)
Cell surface interactions at the vascular wall (Drosophila melanogaster)
Tie2 Signaling (Drosophila melanogaster)
Interaction of Tie2 and Grb2 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
CBL binds to GRB2 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
Binding of GRB2 to GAB1 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2 events in EGFR signaling (Drosophila melanogaster)
GRB2-1 binds SOS1 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Negative regulation of FGFR1 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR2 (Drosophila melanogaster)
Negative regulation of FGFR2 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR3 (Drosophila melanogaster)
Negative regulation of FGFR3 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR4 (Drosophila melanogaster)
Negative regulation of FGFR4 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
GRB2-1 binds SOS1 (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q08012
Gene Names
drk
Reference Genes
BioGPS Gene:36497 drk
CTD Gene:36497 drk
ENSEMBL:FBgn0004638
FlyBase:FBgn0004638
KEGG:dme:Dmel_CG6033 drk
Monarch:36497 drk
NCBI Gene:36497 drk
UCSC:Q08012 drk
Reference Transcript
RefSeq:NM_165996.2 drk
RefSeq:NM_057510.4 drk
RefSeq:NM_165994.2 drk
RefSeq:NM_165998.2 drk
RefSeq:NM_165995.2 drk
Other Identifiers
153747_at
1625475_s_at
36497
GO:0000122
GO:0001784
GO:0005118
GO:0005154
GO:0005515
GO:0005654
GO:0005737
GO:0005886
GO:0006355
GO:0007165
GO:0007173
GO:0007265
GO:0007426
GO:0007427
GO:0007465
GO:0007476
GO:0007605
GO:0007614
GO:0008180
GO:0008286
GO:0008293
GO:0008306
GO:0008355
GO:0008543
GO:0009653
GO:0016020
GO:0030159
GO:0030707
GO:0032991
GO:0043408
GO:0045202
GO:0045500
GO:0045793
GO:0045944
GO:0048010
GO:0048260
GO:0048468
GO:0048856
GO:0048870
GO:0050877
GO:0060090
GO:0070374
GO:0098793
GO:1904263
Participates
as a member of
RHOU effectors [cytosol] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
pFAK:Grb2:Sos [cytosol] (Drosophila melanogaster)
Grb2 bound to Tie2 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
Active FLT3: GRB2 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
as an input of
p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
CBL binds to GRB2 (Drosophila melanogaster)
Interaction of Tie2 and Grb2 (Drosophila melanogaster)
GRB2-1 binds SOS1 (Drosophila melanogaster)
Binding of GRB2 to GAB1 (Drosophila melanogaster)
Other forms of this molecule
drk [cytosol]
drk [plasma membrane]
Inferred From
GRB2-1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_725304.1
,
NP_725303.1
,
NP_476858.1
,
NP_725302.1
,
NP_725306.1
ENSEMBL
FBtr0087698
,
FBgn0004638
,
FBpp0086814
,
FBpp0086816
,
FBtr0087697
,
FBtr0087695
,
FBtr0087694
,
FBtr0087696
,
FBpp0086817
,
FBpp0086815
,
FBpp0086813
FlyBase
FBgn0004638
PRO
Q08012
PDB
2A37
,
2A36
,
2AZV
,
7Y4N
,
2AZS
,
8Z0N
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26675 Sos
4
SOS [cytosol]
(R-DME-205953)
Sos [cytosol]
(R-DME-167221)
phospho-Sos [cytosol]
(R-DME-109821)
Sos [cytosol]
(R-DME-64847)
0.692
3
UniProt:Q9VZZ9
7
phospho-dos [cytosol]
(R-DME-8855574)
dos [cytosol]
(R-DME-508239)
phospho-dos [cytosol]
(R-DME-2685615)
phospho-dos [cytosol]
(R-DME-180496)
phospho-dos [cytosol]
(R-DME-912529)
phospho-dos [cytosol]
(R-DME-180344)
dos [cytosol]
(R-DME-179795)
0.667
6
UniProt:Q9VWM7 Q9VWM7
0.488
2
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