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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
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ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
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dos [cytosol]
Stable Identifier
R-DME-179795
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
GAB1, Q9VZZ9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
Binding of GRB2 to GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1 binds to phosphorylated EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by FGFR2 (Drosophila melanogaster)
Downstream signaling of activated FGFR2 (Drosophila melanogaster)
PI-3K cascade:FGFR2 (Drosophila melanogaster)
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by FGFR3 (Drosophila melanogaster)
Downstream signaling of activated FGFR3 (Drosophila melanogaster)
PI-3K cascade:FGFR3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by FGFR4 (Drosophila melanogaster)
Downstream signaling of activated FGFR4 (Drosophila melanogaster)
PI-3K cascade:FGFR4 (Drosophila melanogaster)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
dos [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VZZ9
Gene Names
dos
Reference Genes
BioGPS Gene:38321 dos
CTD Gene:38321 dos
ENSEMBL:FBgn0016794
FlyBase:FBgn0016794
KEGG Gene (Drosophila melanogaster):Dmel_CG1044 dos
Monarch:38321 dos
NCBI Gene:38321 dos
UCSC:Q9VZZ9 dos
Reference Transcript
RefSeq:NM_079166.3 dos
RefSeq:NM_167956.2 dos
Other Identifiers
141511_at
1640395_a_at
38321
GO:0005515
GO:0005737
GO:0005886
GO:0007165
GO:0007465
GO:0008293
GO:0008595
GO:0016020
GO:0023052
GO:0030154
GO:0035591
GO:0042169
GO:0042461
GO:0045500
GO:0046578
GO:0048856
GO:0060090
Participates
as an input of
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)
Binding of GRB2 to GAB1 (Drosophila melanogaster)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
phospho-dos [cytosol]
phospho-dos [cytosol]
phospho-dos [cytosol]
phospho-dos [cytosol]
dos [cytosol]
phospho-dos [cytosol]
phospho-dos [cytosol]
phospho-dos [cytosol]
Inferred From
GAB1,GAB2 [cytosol]
(Homo sapiens)
GAB1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_523890.2
,
NP_728757.1
Flybase
FBgn0016794
PRO
Q9VZZ9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08012
3
drk [cytosol]
(R-DME-202367)
drk [plasma membrane]
(R-DME-202993)
drk [cytosol]
(R-DME-74686)
0.667
6
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