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PDPK1 [plasma membrane]
Stable Identifier
R-DME-61459
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
Q9W0V1
Locations in the PathwayBrowser
Expand all
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)
AKT1/PDK1 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Regulation of T cell activation by CD28 family (Drosophila melanogaster)
Co-stimulation by CD28 (Drosophila melanogaster)
CD28 dependent PI3K/Akt signaling (Drosophila melanogaster)
AKT binds PDPK1 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
Phosphorylation of PKC theta (Drosophila melanogaster)
PDK1:PIP2,PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)
PDK1:PIP2,PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)
PDK1:PIP2,PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)
AKT1/PDK1 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
AKT binds PDPK1 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1 binds PIP2 (Drosophila melanogaster)
PDPK1:PIP2 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G-protein beta:gamma signalling (Drosophila melanogaster)
G beta:gamma signalling through PI3Kgamma (Drosophila melanogaster)
PIP3 recruits PDK1 and AKT to the membrane (Drosophila melanogaster)
PDK1:AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
Estrogen-stimulated signaling through PRKCZ (Drosophila melanogaster)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PRKCZ recruits RAS in response to estrogen stimulation (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
Activation of AKT2 (Drosophila melanogaster)
PDPK1 binds PIP3 (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1 phosphorylates AKT2 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
Activation of AKT2 (Drosophila melanogaster)
PDPK1 binds PIP3 (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PDPK1 phosphorylates AKT2 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated cell proliferation (Drosophila melanogaster)
PDK1 phosphorylates PKC (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT binds PDPK1 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase Effectors (Drosophila melanogaster)
RHO GTPases activate PKNs (Drosophila melanogaster)
PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1 [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9W0V1 Pdk1
Gene Names
Pdk1, Pk61C, CG1210
Chain
chain:1-836
Reference Genes
BioGPS Gene:38017 Pdk1
KEGG:dme:Dmel_CG1210 Pdk1
Monarch:38017 Pdk1
NCBI Gene:38017 Pdk1
UCSC:Q9W0V1 Pdk1
Reference Transcript
RefSeq:NM_001274254.1 Pdk1
RefSeq:NM_167791.3 Pdk1
RefSeq:NM_167795.3 Pdk1
RefSeq:NM_167793.3 Pdk1
RefSeq:NM_080382.4 Pdk1
RefSeq:NM_167790.3 Pdk1
RefSeq:NM_167792.3 Pdk1
RefSeq:NM_167789.2 Pdk1
RefSeq:NM_167794.3 Pdk1
Other Identifiers
142677_s_at
1629078_s_at
38017
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006915
GO:0007166
GO:0007283
GO:0008284
GO:0008286
GO:0009898
GO:0016301
GO:0016740
GO:0022414
GO:0030154
GO:0030295
GO:0030307
GO:0031594
GO:0034330
GO:0035556
GO:0040018
GO:0043066
GO:0043491
GO:0045793
GO:0046622
GO:0048638
GO:0051124
GO:0065008
GO:0098772
GO:0106310
GO:0140096
GO:1901701
GO:1904262
GO:1904263
Participates
as a member of
AKT1/PDK1 [plasma membrane] (Drosophila melanogaster)
as a component of
PDK1:AKT:PIP3 [plasma membrane] (Drosophila melanogaster)
PDK1:PIP2,PIP3 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP2 [plasma membrane] (Drosophila melanogaster)
PDPK1:PIP3 [plasma membrane] (Drosophila melanogaster)
as an input of
PDPK1 binds PIP3 (Drosophila melanogaster)
Other forms of this molecule
PK61C [cytosol]
phospho-p-S241-PDPK1 [cytosol]
PDPK1 [cytosol]
Inferred From
PDPK1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001261183.1
,
NP_525121.2
,
NP_728474.1
,
NP_728475.1
,
NP_728470.1
,
NP_728476.1
,
NP_728472.1
,
NP_728471.2
,
NP_728473.1
ENSEMBL
FBpp0072366
,
FBtr0333218
,
FBgn0020386
,
FBtr0072464
,
FBpp0305420
FlyBase
FBgn0020386
PRO
Q9W0V1
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