Reactome | tws [cytosol]

tws [cytosol]

Stable Identifier

R-DME-377253

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

PPP2R2A, P36872

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle, Mitotic (Drosophila melanogaster)
  - M Phase (Drosophila melanogaster)
    - Mitotic Metaphase and Anaphase (Drosophila melanogaster)
      - Mitotic Anaphase (Drosophila melanogaster)
        
        Nuclear Envelope (NE) Reassembly (Drosophila melanogaster)
        
        Initiation of Nuclear Envelope (NE) Reformation (Drosophila melanogaster)
        
        ANKLE2 binds PP2A (Drosophila melanogaster)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Drosophila melanogaster)
        
        tws [cytosol] (Drosophila melanogaster)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Drosophila melanogaster)
        
        tws [cytosol] (Drosophila melanogaster)
        
        PP2A dephosphorylates BANF1 (Drosophila melanogaster)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Drosophila melanogaster)
        
        tws [cytosol] (Drosophila melanogaster)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Drosophila melanogaster)
        
        tws [cytosol] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to mechanical stimuli (Drosophila melanogaster)
  - Response of endothelial cells to shear stress (Drosophila melanogaster)
    - Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Drosophila melanogaster)
      - PP2A dephosphorylates serine-127 of YAP1 (Drosophila melanogaster)
        
        p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Drosophila melanogaster)
        
        PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Drosophila melanogaster)
        
        tws [cytosol] (Drosophila melanogaster)

Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Drosophila melanogaster)
        
        tws [cytosol] (Drosophila melanogaster)
      - mRNA Cleaved by SMG6 [cytosol] (Drosophila melanogaster)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Drosophila melanogaster)
        
        tws [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P36872 tws

Gene Names

tws, aar, Pp2A-85F, CG6235

Chain

chain:1-499

Reference Genes

BioGPS Gene:47877 tws

CTD Gene:47877 tws

KEGG:dme:Dmel_CG6235 tws

Monarch:47877 tws

NCBI Gene:47877 tws

UCSC:P36872 tws

Reference Transcript

Other Identifiers

142582_at

151635_s_at

1633501_s_at

47877

GO:0000159

GO:0000278

GO:0005515

GO:0005634

GO:0005829

GO:0007091

GO:0007098

GO:0007163

GO:0007406

GO:0007423

GO:0007447

GO:0019888

GO:0030071

GO:0045201

GO:0045752

GO:0045880

GO:0046599

GO:0048856

GO:0050821

GO:0090263

Participates

as a component of

Other forms of this molecule

TWS [cytosol]

tws [nucleoplasm]

Inferred From

PPP2R2A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_731453.1, NP_476881.1, NP_476880.1, NP_731451.1, NP_731452.1, NP_599112.1, NP_001287269.1, NP_599113.1, NP_599111.1

ENSEMBL

FBpp0311386, FBtr0082186, FBtr0345177, FBpp0081665, FBgn0004889, FBpp0081664, FBtr0082187

FlyBase

FBgn0004889

PRO

P36872