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TWS [cytosol]
Stable Identifier
R-DME-205790
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Dephosphorylation of PER (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phosphorylation of PER and TIM (Drosophila melanogaster)
CRY is phosphorylated by SGG (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
PER is phosphorylated by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)
RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
TIM is phosphorylated by CK2 (Drosophila melanogaster)
RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
N-HH ligand bound to PTC receptor complex (Drosophila melanogaster)
Activation of SMO (Drosophila melanogaster)
Phosphorylation of SMO (Drosophila melanogaster)
Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
N-HH ligand not bound to PTC receptor complex (Drosophila melanogaster)
Assembly of the CI containing complexes (Drosophila melanogaster)
Phosphorylation of CI (Drosophila melanogaster)
Phosphorylation of CI by SGG (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Ubiquitination and proteolysis of phosphorylated CI (Drosophila melanogaster)
SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand bound to FZ receptors (Drosophila melanogaster)
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM (Drosophila melanogaster)
Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
WG ligand not bound to FZ receptors (Drosophila melanogaster)
Assembly of the 'destruction complex' (Drosophila melanogaster)
ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Formation of the 'destruction complex' (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM (Drosophila melanogaster)
Further phosphorylation of ARM by SGG (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC (Drosophila melanogaster)
Further phosphorylation of APC by DCO (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Further phosphorylation of APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
Ubiquitination and degradation of phosphorylated ARM (Drosophila melanogaster)
Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
TWS [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P36872 tws
Gene Names
tws, aar, Pp2A-85F, CG6235
Chain
chain:1-499
Reference Genes
BioGPS Gene:47877 tws
CTD Gene:47877 tws
KEGG:dme:Dmel_CG6235 tws
Monarch:47877 tws
NCBI Gene:47877 tws
UCSC:P36872 tws
Reference Transcript
RefSeq:NM_001300340.1 tws
RefSeq:NM_134284.3 tws
RefSeq:NM_057533.3 tws
RefSeq:NM_169330.2 tws
RefSeq:NM_134285.2 tws
RefSeq:NM_169331.2 tws
RefSeq:NM_169329.2 tws
RefSeq:NM_057532.4 tws
RefSeq:NM_134286.3 tws
Other Identifiers
142582_at
151635_s_at
1633501_s_at
47877
GO:0000159
GO:0000278
GO:0005515
GO:0005634
GO:0005829
GO:0007091
GO:0007098
GO:0007163
GO:0007406
GO:0007423
GO:0007447
GO:0019888
GO:0030071
GO:0045201
GO:0045752
GO:0045880
GO:0046599
GO:0048856
GO:0050821
GO:0090263
Participates
as a component of
PP2A [cytosol] (Drosophila melanogaster)
PP2A [cytosol] (Drosophila melanogaster)
Other forms of this molecule
tws [cytosol]
tws [nucleoplasm]
Cross References
RefSeq
NP_731453.1
,
NP_476881.1
,
NP_476880.1
,
NP_731451.1
,
NP_731452.1
,
NP_599112.1
,
NP_001287269.1
,
NP_599113.1
,
NP_599111.1
ENSEMBL
FBpp0311386
,
FBtr0082186
,
FBtr0345177
,
FBpp0081665
,
FBgn0004889
,
FBpp0081664
,
FBtr0082187
FlyBase
FBgn0004889
PRO
P36872
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