Reactome | raptor [cytosol]

raptor [cytosol]

Stable Identifier

R-DME-3006727

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPTOR, Q9W437

Locations in the PathwayBrowser

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Autophagy (Drosophila melanogaster)

- Macroautophagy (Drosophila melanogaster)
  - Active MTORC1 binds the ULK1 complex (Drosophila melanogaster)
    - Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
      - Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)
  - Active MTORC1 phosphorylates ULK1 (Drosophila melanogaster)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
      - Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
      - Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)
  - Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)
    - Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Drosophila melanogaster)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Drosophila melanogaster)
      - Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - TP53 Regulates Metabolic Genes (Drosophila melanogaster)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)
        
        Active mTORC1 complex [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Drosophila melanogaster)
        
        mTORC1 [cytosol] (Drosophila melanogaster)
        
        raptor [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W437

Gene Names

raptor

Reference Genes

BioGPS Gene:31543 raptor

CTD Gene:31543 raptor

ENSEMBL:FBgn0029840

FlyBase:FBgn0029840

KEGG:dme:Dmel_CG4320 raptor

Monarch:31543 raptor

NCBI Gene:31543 raptor

UCSC:Q9W437 raptor

Reference Transcript

Other Identifiers

144111_at

144574_at

1630756_at

1631177_at

31543

GO:0001934

GO:0005515

GO:0005737

GO:0007517

GO:0007562

GO:0008286

GO:0008340

GO:0009267

GO:0010506

GO:0012501

GO:0016787

GO:0022414

GO:0030307

GO:0030674

GO:0031929

GO:0031931

GO:0034417

GO:0035096

GO:0038202

GO:0045793

GO:0045886

GO:0048477

GO:0048856

GO:0060090

GO:0070062

GO:0071230

GO:1902669

Participates

as a component of

mTORC1 [cytosol] (Drosophila melanogaster)

Other forms of this molecule

raptor [nucleoplasm]

phospho-raptor [cytosol]

Inferred From

RPTOR [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_572294.2, NP_001284924.1

FlyBase

FBgn0029840

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