Deltex recruits Kurtz arrestin to Notch

Stable Identifier
R-DME-2071846
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Deltex recruits Kurtz arrestin to Notch
Kurtz (Krz), encoded by the krz gene, is a Drosophila homologue of human non-visual beta-arrestins ARRB1 and ARRB2. Kurtz was identified as a binding partner of Dx (Deltex) in a yeast two-hybrid screen and also by using the tandem affinity purification-liquid chromatography-mass spectroscopy approach. Binding of Drosophila Kurtz and Deltex was confirmed by co-immunoprecipitation and it was determined that this interaction requires an N-terminal domain of Kurtz and full-length Deltex. Notch can also be co-immunoprecipitated with Kurtz in the presence of Deltex (Mukherjee et al. 2005). Shrub, a core component of the ESCRT-III complex, was recently identified as an important modulator of non-visual beta-arrestin-mediated downregulation of Notch in Drosophila (Hori et al. 2011).
Literature References
PubMed ID Title Journal Year
16284625 Regulation of Notch signalling by non-visual beta-arrestin

Mukherjee, A, Bauer, A, Veraksa, A, Rosse, C, Artavanis-Tsakonas, S, Camonis, J

Nat Cell Biol 2005
22162134 Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal

Hori, K, Sen, A, Artavanis-Tsakonas, S, Kirchhausen, T

J Cell Biol 2011
Participants
Orthologous Events
Authored
Reviewed
Created
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