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ben [cytosol]
Stable Identifier
R-DME-206072
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
UBE2N, P35128
Locations in the PathwayBrowser
Expand all
Autophagy (Drosophila melanogaster)
Macroautophagy (Drosophila melanogaster)
Selective autophagy (Drosophila melanogaster)
Aggrephagy (Drosophila melanogaster)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
Ub:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:PRKN [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Mitophagy (Drosophila melanogaster)
PINK1-PRKN Mediated Mitophagy (Drosophila melanogaster)
PRKN ubiquitinates MOM substrates (Drosophila melanogaster)
UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Transfer of ubiquitin from E1 to E2 (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Ubiquitin:E2 conjugating enzymes [cytosol] (Drosophila melanogaster)
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
K63polyUb-IRAK1 dissociates (Drosophila melanogaster)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Pellino ubiquitinates IRAK1 (Drosophila melanogaster)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TRAF6 is K63 poly-ubiquitinated (Drosophila melanogaster)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Drosophila melanogaster)
IRAK1:Pellino:E2 complexes [cytosol] (Drosophila melanogaster)
IRAK4: p-Pellino-1,2,3:UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK1 recruits IKK complex (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK1 recruits IKK complex (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK1 recruits IKK complex (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK1 recruits IKK complex (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
IRAK1 recruits IKK complex (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Drosophila melanogaster)
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
ben [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P35128 ben
Gene Names
ben, UbcD3, CG18319
Chain
chain:1-151
Reference Genes
BioGPS Gene:32358 ben
CTD Gene:32358 ben
KEGG:dme:Dmel_CG18319 ben
Monarch:32358 ben
NCBI Gene:32358 ben
UCSC:P35128 ben
Reference Transcript
RefSeq:NM_001169281.2 ben
RefSeq:NM_001272611.2 ben
RefSeq:NM_001258734.2 ben
RefSeq:NM_078595.3 ben
RefSeq:NM_001272612.2 ben
Other Identifiers
154256_at
1630855_s_at
1641279_at
32358
GO:0000166
GO:0000209
GO:0002376
GO:0003824
GO:0005524
GO:0005634
GO:0005829
GO:0006281
GO:0006301
GO:0006979
GO:0007409
GO:0007412
GO:0007625
GO:0007629
GO:0007630
GO:0008594
GO:0016567
GO:0016740
GO:0016746
GO:0031372
GO:0031624
GO:0031625
GO:0034330
GO:0043068
GO:0045977
GO:0046330
GO:0048471
GO:0051124
GO:0060074
GO:0061057
GO:0061631
GO:0070534
GO:0072347
GO:0140096
GO:1903265
Participates
as a component of
UBE2N:UBE2V1:K63polyUb [cytosol] (Drosophila melanogaster)
UBE2N:UBE2V1 [cytosol] (Drosophila melanogaster)
as a candidate of
E2 Ubiquitin-conjugating enzyme [cytosol] (Drosophila melanogaster)
Other forms of this molecule
BEN [cytosol]
ben [nucleoplasm]
ben [nucleoplasm]
ben [nucleoplasm]
ben [cytosol]
Inferred From
UBE2N [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001259540.1
,
NP_001162752.1
,
NP_001245663.1
,
NP_001259541.1
,
NP_511150.1
ENSEMBL
FBtr0332844
,
FBtr0332843
,
FBpp0289793
,
FBpp0305066
,
FBpp0305067
,
FBpp0298297
,
FBpp0073686
,
FBtr0300566
,
FBtr0307296
,
FBgn0000173
,
FBtr0073855
FlyBase
FBgn0000173
PRO
P35128
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21461
2
SIAH2 [cytosol]
(R-DME-374566)
SIAH1 [cytosol]
(R-DME-374563)
0.488
2
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