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MYD88 [cytosol]
Stable Identifier
R-DME-206015
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Degradation of NF-kappa-B inhibitor, CACT (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)
DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' (Drosophila melanogaster)
Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
Formation of the trans-membrane 'signalling complex' (Drosophila melanogaster)
Adaptor protein complex binds to TL receptor at the plasma membrane (Drosophila melanogaster)
MYD88:TUB binds to TL receptor (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
MYD88 binds to TUB (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
PLL kinase binds to TUB in the TL receptor 'signalling complex' (Drosophila melanogaster)
PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
MYD88:TUB [cytosol] (Drosophila melanogaster)
MYD88 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q7K105 Myd88
Gene Names
Myd88, CG2078, Dmel_CG2078
Reference Genes
BioGPS Gene:35956 Myd88
KEGG Gene (Drosophila melanogaster):Dmel_CG2078 Myd88
Monarch:35956 Myd88
NCBI Gene:35956 Myd88
UCSC:Q7K105 Myd88
Reference Transcript
RefSeq:NM_001299317.1 Myd88
RefSeq:NM_001273892.1 Myd88
RefSeq:NM_136635.3 Myd88
Other Identifiers
153979_at
1636706_at
35956
GO:0002225
GO:0002347
GO:0002376
GO:0002755
GO:0002804
GO:0005121
GO:0005515
GO:0005546
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0007165
GO:0008063
GO:0008289
GO:0009605
GO:0009898
GO:0009950
GO:0009953
GO:0010046
GO:0019732
GO:0023052
GO:0034142
GO:0035325
GO:0035591
GO:0043123
GO:0045087
GO:0045944
GO:0048856
GO:0050830
GO:0050832
GO:0060090
GO:0070976
GO:0098542
Participates
as a component of
MYD88:TUB [cytosol] (Drosophila melanogaster)
as an input of
MYD88 binds to TUB (Drosophila melanogaster)
Other forms of this molecule
Myd88 [cytosol]
Cross References
RefSeq
NP_610479.1
,
NP_001286246.1
,
NP_001260821.1
Flybase
FBgn0033402
PRO
Q7K105
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08953 Tl
6
TL [plasma membrane]
(R-DME-206218)
Tl [secretory granule membrane]
(R-DME-6804777)
Tl [plasma membrane]
(R-DME-167926)
Tl [plasma membrane]
(R-DME-166045)
Tl [plasma membrane]
(R-DME-168061)
Tl [plasma membrane]
(R-DME-167992)
0.589
3
UniProt:P22812 tub
1
TUB [cytosol]
(R-DME-206155)
0.534
2
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