Reactome | cue [extracellular region]

cue [extracellular region]

Stable Identifier

R-DME-179863

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

extracellular region

Synonyms

EGF, Q95RU0

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        cue [extracellular region] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q95RU0

Gene Names

cue

Reference Genes

BioGPS Gene:38174 cue

ENSEMBL:FBgn0011204

FlyBase:FBgn0011204

KEGG:dme:Dmel_CG12086 cue

Monarch:38174 cue

NCBI Gene:38174 cue

UCSC:Q95RU0 cue

Reference Transcript

RefSeq:NM_138269.3 cue

Other Identifiers

147982_at

1633400_at

38174

GO:0005509

GO:0005886

GO:0007283

GO:0016020

GO:0022414

GO:0030154

GO:0045938

GO:0048477

GO:0048856

GO:0051239

GO:0070328

Participates

as a component of

as an input of

EGFR binds EGF ligand (Drosophila melanogaster)

Other forms of this molecule

cue [extracellular region]

cue [clathrin-coated endocytic vesicle membrane]

cue [extracellular region]

cue [platelet alpha granule lumen]

Inferred From

EGF-like ligands [extracellular region] (Homo sapiens)

EGF [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_612113.2

ENSEMBL

FBgn0011204, FBpp0072590, FBtr0072706

FlyBase

FBgn0011204

PRO

Q95RU0

GlyGen

Q95RU0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-26744520 SELG			0.488	2
UniProt:Q058V3 Q058V3			0.488	2

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