Reactome | Prosalpha4T1 [nucleoplasm]

Prosalpha4T1 [nucleoplasm]

Stable Identifier

R-DME-174351-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

PSMA7, Q24178

Locations in the PathwayBrowser

Expand all

Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G1/S DNA Damage Checkpoints (Drosophila melanogaster)
    - p53-Independent G1/S DNA Damage Checkpoint (Drosophila melanogaster)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Cyclin E associated events during G1/S transition (Drosophila melanogaster)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
      - SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)

DNA Replication (Drosophila melanogaster)

- DNA Replication Pre-Initiation (Drosophila melanogaster)
  - Assembly of the pre-replicative complex (Drosophila melanogaster)
    - Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)
      - 26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX2 (Drosophila melanogaster)
      - Regulation of RUNX2 expression and activity (Drosophila melanogaster)
        
        26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional regulation by RUNX3 (Drosophila melanogaster)
      - Regulation of RUNX3 expression and activity (Drosophila melanogaster)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Hedgehog (Drosophila melanogaster)
  - Hedgehog 'on' state (Drosophila melanogaster)
    - GLI2,3 are degraded by the proteasome (Drosophila melanogaster)
      - 26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP outer ring [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)
        
        Prosalpha4T1 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q24178

Gene Names

Prosalpha4T1

Reference Genes

BioGPS Gene:42457 Prosalpha4T1

ENSEMBL:FBgn0265606

FlyBase:FBgn0265606

KEGG:dme:Dmel_CG17268 Prosalpha4T1

Monarch:42457 Prosalpha4T1

NCBI Gene:42457 Prosalpha4T1

UCSC:Q24178 Prosalpha4T1

Reference Transcript

RefSeq:NM_142653.3 Prosalpha4T1

Other Identifiers

143895_at

1626747_at

42457

GO:0000502

GO:0003674

GO:0005634

GO:0005737

GO:0005839

GO:0006511

GO:0019773

GO:0030163

GO:0043161

GO:0051603

Participates

as a member of

Homologues of PSMA7 [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

Prosalpha4T1 [cytosol]

Inferred From

PSMA7 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_650910.1

ENSEMBL

FBpp0083336, FBtr0083928, FBgn0265606

FlyBase

FBgn0265606

PRO

Q24178

Cite Us!