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Insulin signaling pathway
Stable Identifier
R-DME-110478
Type
Pathway
Species
Drosophila melanogaster
ReviewStatus
5/5
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Drosophila signaling pathways (Drosophila melanogaster)
Insulin receptor mediated signaling (Drosophila melanogaster)
Insulin signaling pathway (Drosophila melanogaster)
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In Drosophila there is a single insulin/IGF receptor homologue (DInr), seven insulin-like peptides (DILPs), and a single IRS homologue (Chico), in contrast to the insulin receptor, insulin and IRS entities, respectively, in mammals. DInr and the DILPs interact to regulate growth, haemolymph carbohydrate levels, reproduction and ageing.
Participants
Events
DILP binds to Drosophila insulin receptor (DINR)
(Drosophila melanogaster)
Autophosphorylation of DINR
(Drosophila melanogaster)
Activated DINR binds Chico
(Drosophila melanogaster)
Chico is phosphorylated
(Drosophila melanogaster)
Phospho-Chico: Activated DINR binds p60:Dp110
(Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by Dp110
(Drosophila melanogaster)
PIP3 dephosphorylated to PIP2 by DPTEN
(Drosophila melanogaster)
Increased PIP3 levels recruit DAkt1 to the membrane
(Drosophila melanogaster)
Activation of DAkt1 by DPDK1
(Drosophila melanogaster)
DAkt1-mediated phosphorylation inactivates DFOXO
(Drosophila melanogaster)
Participates
as an event of
Insulin receptor mediated signaling (Drosophila melanogaster)
Authored
Jassal, B (2004-02-11)
Created
Jassal, B (2004-02-11)
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