Phosphorylation of PIP2 to PIP3 by Dp110

Stable Identifier
R-DME-110453
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of PIP2 to PIP3 by Dp110
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PI3Ks are implicated in cell growth, number and size. Dp110, the Drosophila PI3K, phosphorylates PIP2 -> PIP3 (both intracellular messengers) to continue the signaling mechanism. Overexpression of Dp110 results in enlarged cell size and number suggesting a role for Dp110 in growth and size control.
Literature References
PubMed ID Title Journal Year
8978685 The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

Leevers, SJ, Weinkove, D, MacDougall, LK, Hafen, E, Waterfield, MD

EMBO J 1997
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
phosphatidylinositol phosphate biosynthetic process (0046854)
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p60:Dp110:Phospho-Chico:Activated DINR complex [plasma membrane]

Physical Entity
p60:Dp110:Phospho-Chico:Activated DINR complex [plasma membrane] (Drosophila melanogaster)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Authored
Jassal, B  (2004-02-11)
Created
Jassal, B  (2004-02-11)
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