Phosphorylation of PIP2 to PIP3 by Dp110

Stable Identifier
R-DME-110453
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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PI3Ks are implicated in cell growth, number and size. Dp110, the Drosophila PI3K, phosphorylates PIP2 -> PIP3 (both intracellular messengers) to continue the signaling mechanism. Overexpression of Dp110 results in enlarged cell size and number suggesting a role for Dp110 in growth and size control.

Literature References
PubMed ID Title Journal Year
8978685 The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

Leevers, SJ, Weinkove, D, MacDougall, LK, Hafen, E, Waterfield, MD

EMBO J 1997
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p60:Dp110:Phospho-Chico:Activated DINR complex [plasma membrane]
Physical Entity
Activity
Authored
Created