Reactome | MARK3 [cytosol]

MARK3 [cytosol]

Stable Identifier

R-DDI-5672591

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Q54DF2

Locations in the PathwayBrowser

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Signal Transduction (Dictyostelium discoideum)

- MAPK family signaling cascades (Dictyostelium discoideum)
  - MAPK1/MAPK3 signaling (Dictyostelium discoideum)
    - RAF/MAP kinase cascade (Dictyostelium discoideum)
      - MAP2K and MAPK activation (Dictyostelium discoideum)
        
        Dissociation of RAS:RAF complex (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        RAF/MAPK scaffolds [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF/KSR1 [plasma membrane] (Dictyostelium discoideum)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
      - Negative regulation of MAPK pathway (Dictyostelium discoideum)
        
        BRAP binds KSR1:MARK3 (Dictyostelium discoideum)
        
        BRAP:KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
      - RAF activation (Dictyostelium discoideum)
        
        MARK3 phosphorylates KSR1 (Dictyostelium discoideum)
        
        KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Dictyostelium discoideum)
        
        p-S311 KSR1:MARK3 [cytosol] (Dictyostelium discoideum)
        
        Homologues of MARK3 [cytosol] (Dictyostelium discoideum)
        
        MARK3 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54DF2

Reference Genes

BioGPS Gene:8628605

dictyBase:DDB_G0292304

ENSEMBL:DDB_G0292304

KEGG:ddi:DDB_G0292304

Monarch:8628605

NCBI Gene:8628605

UCSC:Q54DF2

Reference Transcript

RefSeq:XM_629687.1

Participates

as a member of

Homologues of MARK3 [cytosol] (Dictyostelium discoideum)

Inferred From

MARK3 [cytosol] (Homo sapiens)

Cross References

IntEnz

2.7.11.1

PRO

Q54DF2

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