Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-T357,S358-MLKL [cytosol]
Stable Identifier
R-DDI-5218903
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
cytosol
Synonyms
Q86HG9
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Dictyostelium discoideum)
Regulated Necrosis (Dictyostelium discoideum)
RIPK1-mediated regulated necrosis (Dictyostelium discoideum)
MLKL binds PIPs (Dictyostelium discoideum)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
RIPK3 phosphorylates MLKL (Dictyostelium discoideum)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
Regulation of necroptotic cell death (Dictyostelium discoideum)
MLKL binds IP4, IP5 and IP6 (Dictyostelium discoideum)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol] (Dictyostelium discoideum)
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
Transport of small molecules (Dictyostelium discoideum)
Ion channel transport (Dictyostelium discoideum)
Stimuli-sensing channels (Dictyostelium discoideum)
TRP channels (Dictyostelium discoideum)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)
p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
phospho-p-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:Q86HG9
Reference Genes
BioGPS Gene:8618113
dictyBase:DDB_G0271682
ENSEMBL:DDB_G0271682
KEGG:ddi:DDB_G0271682
Monarch:8618113
NCBI Gene:8618113
UCSC:Q86HG9
Reference Transcript
RefSeq:XM_640393.1
Participates
as a repeated unit of
p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)
as a component of
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] (Dictyostelium discoideum)
Other forms of this molecule
MLKL [cytosol]
Inferred From
p-T357,S358-MLKL [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 358 (in Homo sapiens)
Coordinate
358
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 357 (in Homo sapiens)
Coordinate
357
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_645485.1
PRO
Q86HG9
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text