Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Homologues of K63polyUb-TRAF6 [cytosol]
Stable Identifier
R-DDI-2685681-25
Type
Set [DefinedSet]
Species
Dictyostelium discoideum
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Dictyostelium discoideum)
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Signaling by Interleukins (Dictyostelium discoideum)
Interleukin-1 family signaling (Dictyostelium discoideum)
Interleukin-1 signaling (Dictyostelium discoideum)
TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Dictyostelium discoideum)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Interleukin-17 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Toll-like Receptor Cascades (Dictyostelium discoideum)
Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
MyD88-independent TLR4 cascade (Dictyostelium discoideum)
TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
MAP kinase activation (Dictyostelium discoideum)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Deubiquitination (Dictyostelium discoideum)
Ub-specific processing proteases (Dictyostelium discoideum)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Dictyostelium discoideum)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Dictyostelium discoideum)
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Dictyostelium discoideum)
Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
Participants
members
zfaA [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
K63polyUb-TRAF6 [cytosol]
(Dictyostelium discoideum)
Participates
as a member of
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Dictyostelium discoideum)
as a component of
hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Dictyostelium discoideum)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
Inferred From
K63polyUb-TRAF6 [cytosol]
(Homo sapiens)
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
