Reactome | K63polyUb-TRAF6 [cytosol]

K63polyUb-TRAF6 [cytosol]

Stable Identifier

R-DDI-2685681-22

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Q86K46

Locations in the PathwayBrowser

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Immune System (Dictyostelium discoideum)

- Cytokine Signaling in Immune system (Dictyostelium discoideum)
  - Signaling by Interleukins (Dictyostelium discoideum)
    - Interleukin-1 family signaling (Dictyostelium discoideum)
      - Interleukin-1 signaling (Dictyostelium discoideum)
        
        TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Dictyostelium discoideum)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
    - Interleukin-17 signaling (Dictyostelium discoideum)
      - MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
- Innate Immune System (Dictyostelium discoideum)
  - Toll-like Receptor Cascades (Dictyostelium discoideum)
    - Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
      - Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
      - Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
      - MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
      - MyD88-independent TLR4 cascade (Dictyostelium discoideum)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
    - Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Dictyostelium discoideum)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        activated TAK1 mediates p38 MAPK activation (Dictyostelium discoideum)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Dictyostelium discoideum)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)

Metabolism of proteins (Dictyostelium discoideum)

- Post-translational protein modification (Dictyostelium discoideum)
  - Deubiquitination (Dictyostelium discoideum)
    - Ub-specific processing proteases (Dictyostelium discoideum)
      - CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Dictyostelium discoideum)
        
        CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Dictyostelium discoideum)
        
        Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)
        
        K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q86K46

Reference Genes

BioGPS Gene:8620937

dictyBase:DDB_G0277243

ENSEMBL:DDB_G0277243

KEGG:ddi:DDB_G0277243

Monarch:8620937

NCBI Gene:8620937

UCSC:Q86K46

Reference Transcript

RefSeq:XM_637655.1

Participates

as a member of

Homologues of K63polyUb-TRAF6 [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

K63polyUb-TRAF2 [cytosol]

PolyUb-TRAF6 [cytosol]

PolyUb-TRAF2 [cytosol]

TRAF1(164-416) [cytosol]

TRAF1(1-163) [cytosol]

TRAF1 [cytosol]

TRAF3 [cytosol]

TRAF2 [cytosol]

TRAF6 [endosome membrane]

K63polyUb-TRAF6 [endosome membrane]

TRAF6 [plasma membrane]

K63polyUb-TRAF6 [plasma membrane]

TRAF6 [cytosol]

Inferred From

K63polyUb-TRAF6 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 124 (in Homo sapiens)

Coordinate

124

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_642747.1

PRO

Q86K46

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