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phospho-p-T309,S474-AKT2 [cytosol]
Stable Identifier
R-DDI-202062
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
cytosol
Synonyms
P54644
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Regulation of T cell activation by CD28 family (Dictyostelium discoideum)
Co-inhibition by CTLA4 (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
AKT phosphorylates targets in the cytosol (Dictyostelium discoideum)
AKT phosphorylates MKRN1 (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PHLPP dephosphorylates S473 in AKT (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
PTEN Regulation (Dictyostelium discoideum)
Regulation of PTEN stability and activity (Dictyostelium discoideum)
AKT phosphorylates MKRN1 (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
MTOR signalling (Dictyostelium discoideum)
Inhibition of TSC complex formation by AKT (PKB) (Dictyostelium discoideum)
Phosphorylation of TSC2 by AKT (PKB) (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by Insulin receptor (Dictyostelium discoideum)
Insulin receptor signalling cascade (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
Activation of AKT2 (Dictyostelium discoideum)
PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Dictyostelium discoideum)
IGF1R signaling cascade (Dictyostelium discoideum)
IRS-related events triggered by IGF1R (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
Activation of AKT2 (Dictyostelium discoideum)
PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
phospho-p-T309,S474-AKT2 [cytosol] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:P54644
Reference Genes
BioGPS Gene:8616573
dictyBase:DDB_G0268620
ENSEMBL:DDB_G0268620
KEGG:ddi:DDB_G0268620
Monarch:8616573
NCBI Gene:8616573
UCSC:P54644
Reference Transcript
RefSeq:XM_641796.1
Participates
as a member of
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
as a component of
p-T309,S474-AKT2:PIP3 [plasma membrane] (Dictyostelium discoideum)
as a candidate of
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-pS, p-T410-PRKCZ [cytosol]
PRKCD(330-676) [extracellular region]
PRKCD(1-329) [extracellular region]
PRKCD(1-329) [azurophil granule lumen]
PRKCD(330-676) [azurophil granule lumen]
phospho-p-T308,S473-AKT1 [plasma membrane]
PRKCH [cytosol]
phospho-p-T497,T638,S657-PRKCA [nucleoplasm]
phospho-p-T500,T642,S661-PRKCB [nucleoplasm]
PRKCZ [cytosol]
PRKCB [cytosol]
phospho-p-T410-PRKCZ [cytosol]
phospho-p-T500-PRKCB [cytosol]
phospho-p-T507-PRKCD [cytosol]
phospho-p-T497-PRKCA [cytosol]
phospho-p-T500,T642,S661-PRKCB [cytosol]
phospho-p-T410,T563-PRKCZ [cytosol]
phospho-p-T507,S645,S664-PRKCD [cytosol]
phospho-p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
PRKCQ [plasma membrane]
phospho-p-Y90-PRKCQ [plasma membrane]
PRKCB [plasma membrane]
PRKCA [plasma membrane]
phospho-p-T497,T638,S657-PRKCA [cytosol]
phospho-p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
PRKCG [cytosol]
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
phospho-p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
phospho-p-T309,S474-AKT2 [nucleoplasm]
phospho-p-T305,S472-AKT3 [nucleoplasm]
phospho-p-T308,S473-AKT1 [nucleoplasm]
phospho-p-T305,S472-AKT3 [cytosol]
phospho-p-T308,S473-AKT1 [cytosol]
phospho-p-S474-AKT2 [plasma membrane]
phospho-p-S472-AKT3 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
AKT2 [plasma membrane]
AKT3 [plasma membrane]
AKT1 [plasma membrane]
AKT2 [cytosol]
AKT3 [cytosol]
AKT1 [cytosol]
PRKCA [cytosol]
phospho-p-T256,S422-SGK1 [nucleoplasm]
PRKCD [cytosol]
phospho-p-T774-PKN1 [cytosol]
PKN3 [cytosol]
PKN1 [cytosol]
PKN2 [cytosol]
phospho-p-T816-PKN2 [cytosol]
phospho-p-T256,S422-SGK1 [cytosol]
phospho-p-S422-SGK1 [cytosol]
SGK1 [cytosol]
PRKCQ [cytosol]
PRKCQ(355-706) [cytosol]
PRKCQ(1-354) [cytosol]
PRKCD(1-329) [cytosol]
PRKCD(330-676) [cytosol]
phospho-p-T309-AKT2 [cytosol]
phospho-p-T305-AKT3 [cytosol]
phospho-p-T308-AKT1 [cytosol]
PRKCE [cytosol]
Inferred From
p-T309,S474-AKT2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 309 (in Homo sapiens)
Coordinate
309
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 474 (in Homo sapiens)
Coordinate
474
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_646888.1
PRO
P54644
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