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phospho-p-T308,S473-AKT1 [cytosol]
Stable Identifier
R-DDI-198356
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
cytosol
Synonyms
P54644
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Regulation of T cell activation by CD28 family (Dictyostelium discoideum)
Co-inhibition by CTLA4 (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Metabolism (Dictyostelium discoideum)
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
eNOS activation (Dictyostelium discoideum)
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Metabolism of RNA (Dictyostelium discoideum)
Regulation of mRNA stability by proteins that bind AU-rich elements (Dictyostelium discoideum)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Dictyostelium discoideum)
Protein Kinase B/Akt phosphorylates BRF1 (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
AKT phosphorylates targets in the cytosol (Dictyostelium discoideum)
AKT phosphorylates MKRN1 (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PHLPP dephosphorylates S473 in AKT (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
PTEN Regulation (Dictyostelium discoideum)
Regulation of PTEN stability and activity (Dictyostelium discoideum)
AKT phosphorylates MKRN1 (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
MTOR signalling (Dictyostelium discoideum)
Inhibition of TSC complex formation by AKT (PKB) (Dictyostelium discoideum)
Phosphorylation of TSC2 by AKT (PKB) (Dictyostelium discoideum)
p-T,p-S-AKT [cytosol] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
phospho-p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:P54644
Reference Genes
BioGPS Gene:8616573
dictyBase:DDB_G0268620
ENSEMBL:DDB_G0268620
KEGG:ddi:DDB_G0268620
Monarch:8616573
NCBI Gene:8616573
UCSC:P54644
Reference Transcript
RefSeq:XM_641796.1
Participates
as a member of
Homologues of p-T308,S473-AKT1 [cytosol] (Dictyostelium discoideum)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-pS, p-T410-PRKCZ [cytosol]
PRKCD(330-676) [extracellular region]
PRKCD(1-329) [extracellular region]
PRKCD(1-329) [azurophil granule lumen]
PRKCD(330-676) [azurophil granule lumen]
phospho-p-T308,S473-AKT1 [plasma membrane]
PRKCH [cytosol]
phospho-p-T497,T638,S657-PRKCA [nucleoplasm]
phospho-p-T500,T642,S661-PRKCB [nucleoplasm]
PRKCZ [cytosol]
PRKCB [cytosol]
phospho-p-T410-PRKCZ [cytosol]
phospho-p-T500-PRKCB [cytosol]
phospho-p-T507-PRKCD [cytosol]
phospho-p-T497-PRKCA [cytosol]
phospho-p-T500,T642,S661-PRKCB [cytosol]
phospho-p-T410,T563-PRKCZ [cytosol]
phospho-p-T507,S645,S664-PRKCD [cytosol]
phospho-p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
PRKCQ [plasma membrane]
phospho-p-Y90-PRKCQ [plasma membrane]
PRKCB [plasma membrane]
PRKCA [plasma membrane]
phospho-p-T497,T638,S657-PRKCA [cytosol]
phospho-p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
PRKCG [cytosol]
phospho-p-T566,T710,S729-PRKCE [plasma membrane]
phospho-p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
phospho-p-T309,S474-AKT2 [nucleoplasm]
phospho-p-T305,S472-AKT3 [nucleoplasm]
phospho-p-T308,S473-AKT1 [nucleoplasm]
phospho-p-T305,S472-AKT3 [cytosol]
phospho-p-T309,S474-AKT2 [cytosol]
phospho-p-S474-AKT2 [plasma membrane]
phospho-p-S472-AKT3 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
AKT2 [plasma membrane]
AKT3 [plasma membrane]
AKT1 [plasma membrane]
AKT2 [cytosol]
AKT3 [cytosol]
AKT1 [cytosol]
PRKCA [cytosol]
phospho-p-T256,S422-SGK1 [nucleoplasm]
PRKCD [cytosol]
phospho-p-T774-PKN1 [cytosol]
PKN3 [cytosol]
PKN1 [cytosol]
PKN2 [cytosol]
phospho-p-T816-PKN2 [cytosol]
phospho-p-T256,S422-SGK1 [cytosol]
phospho-p-S422-SGK1 [cytosol]
SGK1 [cytosol]
PRKCQ [cytosol]
PRKCQ(355-706) [cytosol]
PRKCQ(1-354) [cytosol]
PRKCD(1-329) [cytosol]
PRKCD(330-676) [cytosol]
phospho-p-T309-AKT2 [cytosol]
phospho-p-T305-AKT3 [cytosol]
phospho-p-T308-AKT1 [cytosol]
PRKCE [cytosol]
Inferred From
p-T308,S473-AKT1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308 (in Homo sapiens)
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473 (in Homo sapiens)
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_646888.1
PRO
P54644
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