Reactome | ALKAL2 [extracellular region]

ALKAL2 [extracellular region]

Stable Identifier

R-CFA-9842575

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

HC-ALKAL2, A0A8I3NYE8

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by ALK (Canis familiaris)
    - ALK autophosphorylation (Canis familiaris)
      - ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
        
        ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - ALK binds ALKAL ligand (Canis familiaris)
      - ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK binds JAK3 (Canis familiaris)
      - Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:JAK3 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK binds PLCG1 (Canis familiaris)
      - Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK binds SHC1 (Canis familiaris)
      - Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:SHC1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK dimer binds IRS1 (Canis familiaris)
      - Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:IRS1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK phosphorylates IRS1 (Canis familiaris)
      - Active ALK:IRS1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:pY-IRS1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK phosphorylates JAK3 (Canis familiaris)
      - Active ALK:JAK3 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:p-Y980 JAK3 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK phosphorylates PLCG1 (Canis familiaris)
      - Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:p-4Y PLCG1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK phosphorylates SHC1 (Canis familiaris)
      - Active ALK:SHC1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:p-3Y SHC1 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Active ALK recruits PI3K (Canis familiaris)
      - Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:PI3K [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - Liganded-ALK dimer binds type I ALK-binding TKIs (Canis familiaris)
      - ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
        
        ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
      - Active ALK:PI3K [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - PTPN6 dephosphorylates JAK3 (Canis familiaris)
      - Active ALK:JAK3 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
      - Active ALK:p-Y980 JAK3 [plasma membrane] (Canis familiaris)
        
        Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)
    - STAT3 is phosphorylated downstream of active ALK (Canis familiaris)
      - Active ALK dimer [plasma membrane] (Canis familiaris)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Canis familiaris)
        
        ALKAL2:(ALKAL1) [extracellular region] (Canis familiaris)
        
        ALKAL2 dimer [extracellular region] (Canis familiaris)
        
        ALKAL2 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NYE8

Gene Names

ALKAL2

Reference Genes

ENSEMBL:ENSCAFG00845017008.1

UCSC:A0A8I3NYE8 ALKAL2

Other Identifiers

102155602

Cfa.12248.1.A1_at

CfaAffx.23539.1.S1_at

GO:0030298

GO:0030971

GO:0098772

Participates

as a component of

ALKAL2 dimer [extracellular region] (Canis familiaris)

Inferred From

HC-ALKAL2 [extracellular region] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via L-cystine (cross-link) at 66 and 66 (in Homo sapiens)

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

ENSEMBL

ENSCAFT00845030121, ENSCAFP00845023626, ENSCAFG00845017008

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