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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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ORCID Integration Project
COVID-19 Disease Pathways
Docs
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How do I search ?
Details Panel
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Analyse gene expression
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TGFA [extracellular region]
Stable Identifier
R-CFA-9624183
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
TGFA(40-89), A0A8I3Q314
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
PTK2 autophosphorylates downstream of EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PTK2 binds activated EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR autophosphorylation (Canis familiaris)
EGF-like ligands:EGFR dimer [plasma membrane] (Canis familiaris)
EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR binds EGF ligand (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR dimerization (Canis familiaris)
EGF-like ligands:EGFR dimer [plasma membrane] (Canis familiaris)
EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR downregulation (Canis familiaris)
Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Binding of CBL to EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
CBL ubiquitinates Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
CBL-mediated ubiquitination of CIN85 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR non-clathrin mediated endocytosis (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR phosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Localization of CBL:GRB2 to the membrane (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PTPN3 dephosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Sprouty sequesters CBL away from active EGFR (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR interacts with phospholipase C-gamma (Canis familiaris)
Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
GAB1 signalosome (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Dephosphorylation of PAG by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
GAB1 phosphorylation by EGFR kinase (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Phospho-EGFR (-Y1016) dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:Phospho-EGFR (- Y992) [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
GRB2 events in EGFR signaling (Canis familiaris)
GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Phosphorylation of EGFR by SRC kinase (Canis familiaris)
EGF-like ligands:EGFR dimer [plasma membrane] (Canis familiaris)
EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SHC1 events in EGFR signaling (Canis familiaris)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
Epsin family proteins bind ubiquitinated cargo (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
EGF-like ligands [extracellular region] (Canis familiaris)
TGFA [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3Q314
Gene Names
TGFA
Reference Genes
ENSEMBL:ENSCAFG00845027844.1
UCSC:A0A8I3Q314 TGFA
Other Identifiers
403431
Cfa.133.1.S1_s_at
CfaAffx.5980.1.S1_at
GO:0005102
GO:0005576
GO:0005615
GO:0007165
GO:0008083
GO:0008284
GO:0016020
GO:0048018
GO:0051781
GO:0098772
Participates
as a member of
EGF-like ligands [extracellular region] (Canis familiaris)
Other forms of this molecule
TGFA [clathrin-coated endocytic vesicle membrane]
TGFA [endoplasmic reticulum-Golgi intermediate compartment membrane]
TGFA [ER to Golgi transport vesicle membrane]
TGFA [endoplasmic reticulum membrane]
Inferred From
TGFA(40-89) [extracellular region]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845049238
,
ENSCAFG00845027844
,
ENSCAFP00845038640
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