Reactome | phospho-IL4R [plasma membrane]

phospho-IL4R [plasma membrane]

Stable Identifier

R-CFA-6786087

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

p-Y-IL4R, A0A8I3MUC6

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-4 and Interleukin-13 signaling (Canis familiaris)
      - IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
      - JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
      - STAT1,STAT3,STAT6 bind IL13:IL13R type II (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
      - STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
      - STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
      - p-Y-STATs dissociate (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        p-Y-IL4R:JAK2 [plasma membrane] (Canis familiaris)
        
        phospho-IL4R [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MUC6

Gene Names

IL4R

Reference Genes

BioGPS Gene:489957 IL4R

ENSEMBL:ENSCAFG00845004286.1

Monarch:489957 IL4R

NCBI Gene:489957 IL4R

UCSC:A0A8I3MUC6 IL4R

Reference Transcript

Other Identifiers

489957

Cfa.15373.1.A1_at

CfaAffx.26708.1.S1_s_at

GO:0002376

GO:0002532

GO:0002639

GO:0004896

GO:0004913

GO:0005515

GO:0005654

GO:0005886

GO:0009897

GO:0016020

GO:0016064

GO:0030154

GO:0032722

GO:0034451

GO:0035771

GO:0042832

GO:0043032

GO:0043235

GO:0043306

GO:0045063

GO:0045064

GO:0045626

GO:0045630

GO:0098542

GO:0120162

GO:1901741

Participates

as a component of

Other forms of this molecule

IL4R [plasma membrane]

Inferred From

p-Y-IL4R [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_038524716.1, XP_038524715.1, XP_038524717.1, XP_038524718.1

ENSEMBL

ENSCAFP00845006105, ENSCAFG00845004286, ENSCAFT00845007715

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