Reactome | activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

Stable Identifier

R-CFA-5672723

Type

Complex

Species

Canis familiaris

Compartment

plasma membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

MAPKs [cytosol] (Canis familiaris)
p-S222,S226 MAP2K2 dimer [cytosol] (Canis familiaris)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)

Participates

as an input of

Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
MAP2Ks phosphorylate MAPKs (Canis familiaris)

as an output of

RAF phosphorylates MAP2K dimer (Canis familiaris)

as a component of

activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)

Inferred From

activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)

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