Reactome | MARK3 [cytosol]

MARK3 [cytosol]

Stable Identifier

R-CFA-5672591

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

MARK3, A0A8I3PDX9

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - MAP2K and MAPK activation (Canis familiaris)
        
        Dissociation of RAS:RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        MAP2Ks phosphorylate MAPKs (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        RAF phosphorylates MAP2K dimer (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Canis familiaris)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Canis familiaris)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
      - Negative regulation of MAPK pathway (Canis familiaris)
        
        BRAP binds KSR1:MARK3 (Canis familiaris)
        
        BRAP:KSR1:MARK3 [cytosol] (Canis familiaris)
        
        KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
      - RAF activation (Canis familiaris)
        
        MARK3 phosphorylates KSR1 (Canis familiaris)
        
        KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        Phosphorylation of RAF (Canis familiaris)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Canis familiaris)
        
        activated RAF/KSR1 [plasma membrane] (Canis familiaris)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Canis familiaris)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        Raf dimer inhibitors bind RAF heterodimers (Canis familiaris)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Canis familiaris)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Canis familiaris)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Canis familiaris)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Canis familiaris)
        
        p-S311 KSR1:MARK3 [cytosol] (Canis familiaris)
        
        MARK3 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PDX9

Gene Names

MARK3

Reference Genes

BioGPS Gene:611285 MARK3

ENSEMBL:ENSCAFG00845018426.1

KEGG:cfa:611285 MARK3

Monarch:611285 MARK3

NCBI Gene:611285 MARK3

UCSC:A0A8I3PDX9 MARK3

Reference Transcript

Other Identifiers

611285

CfaAffx.27958.1.S1_s_at

CfaAffx.27961.1.S1_s_at

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005737

GO:0005886

GO:0006468

GO:0010389

GO:0016301

GO:0016740

GO:0019903

GO:0030425

GO:0035331

GO:0042995

GO:0140096

GO:1900181

Participates

as a component of

Inferred From

MARK3 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFT00845032782, ENSCAFG00845018426, ENSCAFP00845025655

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