Reactome | GNAI3 [plasma membrane]

GNAI3 [plasma membrane]

Stable Identifier

R-CFA-55365

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

A0A8I3RSE4

Locations in the PathwayBrowser

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Hemostasis (Canis familiaris)

- Platelet activation, signaling and aggregation (Canis familiaris)
  - Signal amplification (Canis familiaris)
    - ADP signalling through P2Y purinoceptor 12 (Canis familiaris)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Gi activation by P2Y purinoceptor 12 (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)

Neuronal System (Canis familiaris)

- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
    - GABA receptor activation (Canis familiaris)
      - GABA B receptor activation (Canis familiaris)
        
        Activation of GABAB receptors (Canis familiaris)
        
        Adenylate cyclase inhibitory pathway (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Dissociation of the Gi alpha:G olf complex (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Active G alpha (i)–i1/i2/i3 binds RGS proteins (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G alpha (i):GTP:RGS [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Canis familiaris)
        
        G alpha (i):GDP:RGS [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)
        
        G alpha (i):GDP:RGS [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G alpha (i):GTP:RGS [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G alpha (i):GTP:SRC-1 [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G protein alpha (i):GTP:p-Y419-SRC [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G protein alpha (i):GTP:p-Y419-SRC [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Inactive G alpha (i) reassociates with G beta:gamma (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Opioid Signalling (Canis familiaris)
        
        G-protein mediated events (Canis familiaris)
        
        Adenylate cyclase inhibitory pathway (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Dissociation of the Gi alpha:G olf complex (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
- Signaling by Nuclear Receptors (Canis familiaris)
  - ESR-mediated signaling (Canis familiaris)
    - Extra-nuclear estrogen signaling (Canis familiaris)
      - G-proteins dissociate from plasma-membrane estrogen receptors (Canis familiaris)
        
        ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Canis familiaris)
        
        ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)
      - Membrane estrogen receptors bind SRC (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        Homologues of GNAI3 [plasma membrane] (Canis familiaris)
        
        GNAI3 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RSE4

Reference Genes

BioGPS Gene:611810

ENSEMBL:ENSCAFG00845002724.1

Monarch:611810

NCBI Gene:611810

UCSC:A0A8I3RSE4

Reference Transcript

Other Identifiers

611810

Cfa.19948.1.S1_s_at

Cfa.2807.1.S1_at

CfaAffx.30335.1.S1_at

GO:0000139

GO:0000166

GO:0003924

GO:0005525

GO:0005654

GO:0005730

GO:0005737

GO:0005789

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007193

GO:0016020

GO:0016239

GO:0016787

GO:0019001

GO:0019003

GO:0030496

GO:0031683

GO:0034451

GO:0036064

GO:0046039

GO:0046872

GO:0051301

GO:0055086

GO:1901135

Participates

as a member of

Homologues of GNAI3 [plasma membrane] (Canis familiaris)

Inferred From

GNAI3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_038525800.1, XP_038396995.1, XP_854614.3

ENSEMBL

ENSCAFG00845002724, ENSCAFP00845003871, ENSCAFT00845004840

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