Reactome | phospho-JAK1 [cytosol]

phospho-JAK1 [cytosol]

Stable Identifier

R-CFA-451921

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-Y-JAK1, A0A8I3RS40

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Interferon Signaling (Canis familiaris)
    - Interferon alpha/beta signaling (Canis familiaris)
      - Activation of JAK kinases (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Formation of p-STAT1 homodimer (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Phosphorylation of INFAR1 by TYK2 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Phosphorylation of STAT2 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Recruitment of STAT2 to p-IFNAR1 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Regulation of IFNA/IFNB signaling (Canis familiaris)
        
        Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Release of p-STAT2:p-STAT1 dimer (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Canis familiaris)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
    - Interferon gamma signaling (Canis familiaris)
      - Binding of STAT1 to p-IFNGR1 (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - IFNG signaling activates MAPKs (Canis familiaris)
        
        Activated JAK1 binds RAF1 (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        JAK1-mediated phosphorylation of RAF1 (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Phosphorylation of IFNGR1 by JAK kinases (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Phosphorylation of STAT1 at Ser727 (Canis familiaris)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Phosphorylation of STAT1 by JAK kinases (Canis familiaris)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Release of STAT1 dimer from active receptor unit (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Canis familiaris)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Transphosphorylation of JAK1 (Canis familiaris)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Canis familiaris)
        
        IFNGR complex with p-JAK [plasma membrane] (Canis familiaris)
        
        IFNGR1:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
  - Signaling by CSF3 (G-CSF) (Canis familiaris)
    - Inactivation of CSF3 (G-CSF) signaling (Canis familiaris)
      - CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Canis familiaris)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Canis familiaris)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Canis familiaris)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Canis familiaris)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Canis familiaris)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Canis familiaris)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Canis familiaris)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Canis familiaris)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Canis familiaris)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
    - p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)
      - CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Canis familiaris)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Canis familiaris)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-10 signaling (Canis familiaris)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Canis familiaris)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Canis familiaris)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
    - Interleukin-2 family signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits SHIP (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Interleukin-15 signaling (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Interleukin-2 signaling (Canis familiaris)
        
        JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylated STAT5 is released (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylation of IL2RB Y338 enables SHC recruitment (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Recruited STAT5 is phosphorylated (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        SHC1 bound to IL2 receptor is phosphorylated (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        SHC kinases in IL2 signaling [cytosol] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        SYK binds IL2RB (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        SYK is a substrate for JAK1 (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Within the IL-2R complex JAK3 phosphorylates JAK1 (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Canis familiaris)
        
        IL2RA:IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        IL2RB:p-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - Interleukin-21 signaling (Canis familiaris)
        
        IL21 receptor JAK phosphorylation (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL21 receptor STAT binding (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL21 receptor STAT phosphorylation (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Canis familiaris)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits SHIP (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
    - Interleukin-4 and Interleukin-13 signaling (Canis familiaris)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        phospho-JAK1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RS40

Gene Names

JAK1

Reference Genes

ENSEMBL:ENSCAFG00845004547.1

UCSC:A0A8I3RS40 JAK1

Other Identifiers

442952

Cfa.10348.1.S1_at

Cfa.15782.2.S1_s_at

Cfa.5836.1.A1_at

CfaAffx.28443.1.S1_s_at

CfaAffx.28446.1.S1_at

CfaAffx.28447.1.S1_s_at

GO:0003824

GO:0004713

GO:0004715

GO:0005524

GO:0005634

GO:0005737

GO:0005856

GO:0007259

GO:0009898

GO:0012505

GO:0016020

GO:0016740

GO:0019221

GO:0019903

GO:0031234

GO:0031625

GO:0034112

GO:0035556

GO:0035723

GO:0035771

GO:0038110

GO:0038113

GO:0038154

GO:0043226

GO:0046677

GO:0060333

GO:0060337

GO:0070102

GO:0140096

GO:0140105

GO:0150105

GO:1900182

GO:1903672

Participates

as a component of

as a candidate of

SHC kinases in IL2 signaling [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-JAK1 [cytosol]

JAK1 [endosome]

phospho-JAK1 [cytosol]

JAK1 [cytosol]

Inferred From

p-Y-JAK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ENSEMBL

ENSCAFT00845008187, ENSCAFP00845006435

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