Reactome | phospho-VAV1 [cytosol]

phospho-VAV1 [cytosol]

Stable Identifier

R-CFA-437946

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-Y174-VAV1, A0A8I3NA65

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - Src kinases phosphorylate VAV (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
      - VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
      - VEGFR2 mediated vascular permeability (Canis familiaris)
        
        PAK1-3 autophosphorylates (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
        
        PAK1-3 dimer disassociates (Canis familiaris)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
        
        RAC1 binds PAK1-3 (Canis familiaris)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
      - p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NA65

Gene Names

VAV1

Reference Genes

BioGPS Gene:485016 VAV1

ENSEMBL:ENSCAFG00845008896.1

Monarch:485016 VAV1

NCBI Gene:485016 VAV1

UCSC:A0A8I3NA65 VAV1

Reference Transcript

Other Identifiers

485016

CfaAffx.28423.1.S1_s_at

GO:0001784

GO:0002376

GO:0005085

GO:0005515

GO:0005737

GO:0005911

GO:0006909

GO:0006955

GO:0007166

GO:0007186

GO:0007229

GO:0008270

GO:0016192

GO:0030101

GO:0030154

GO:0030217

GO:0030593

GO:0031295

GO:0035556

GO:0042100

GO:0042110

GO:0042267

GO:0045785

GO:0045954

GO:0046872

GO:0048870

GO:0050776

GO:0072593

GO:0140031

Participates

as a member of

Other forms of this molecule

phospho-VAV1 [plasma membrane]

VAV1 [cytosol]

VAV1 [plasma membrane]

Inferred From

p-Y174-VAV1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 174 (in Homo sapiens)

Coordinate

174

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_542134.2, XP_038423457.1, XP_038284778.1

ENSEMBL

ENSCAFP00845012298, ENSCAFT00845015810, ENSCAFG00845008896

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