Reactome | LOC119877881 [nucleoplasm]

LOC119877881 [nucleoplasm]

Stable Identifier

R-CFA-427378

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

Me2K10-HIST1H3A, J9PB22

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- Epigenetic regulation of gene expression (Canis familiaris)
  - Negative epigenetic regulation of rRNA expression (Canis familiaris)
    - NoRC negatively regulates rRNA expression (Canis familiaris)
      - MBD2 binds methylcytosine in chromatin (Canis familiaris)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Canis familiaris)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
    - SIRT1 negatively regulates rRNA expression (Canis familiaris)
      - Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)
        
        Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
        
        eNoSC [nucleoplasm] (Canis familiaris)
        
        Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
      - eNoSC deacetylates histone H3 (Canis familiaris)
        
        eNoSC [nucleoplasm] (Canis familiaris)
        
        Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
      - eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)
        
        Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
        
        eNoSC [nucleoplasm] (Canis familiaris)
        
        Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
- RNA Polymerase I Transcription (Canis familiaris)
  - RNA Polymerase I Promoter Clearance (Canis familiaris)
    - RNA Polymerase I Promoter Escape (Canis familiaris)
      - Elongation of pre-rRNA transcript (Canis familiaris)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Canis familiaris)
        
        Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
    - RNA Polymerase I Promoter Opening (Canis familiaris)
      - UBF-1 Binds rDNA Promoter (Canis familiaris)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Canis familiaris)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Nuclear Receptors (Canis familiaris)
  - ESR-mediated signaling (Canis familiaris)
    - Estrogen-dependent gene expression (Canis familiaris)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Canis familiaris)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
      - KDM1A is recruited to MYC and BCL2 genes (Canis familiaris)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Canis familiaris)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
      - Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Canis familiaris)
        
        MYC gene, BCL2 gene: H3K9me2 nucleosome [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)
        
        LOC119877881 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9PB22

Gene Names

LOC119877881

Reference Genes

BioGPS Gene:119877881 LOC119877881

BioGPS Gene:488263 LOC119877881

ENSEMBL:ENSCAFG00845026157.1

KEGG:cfa:106558266 LOC119877881

KEGG:cfa:115945196 LOC119877881

KEGG:cfa:488263 LOC119877881

Monarch:119877881 LOC119877881

Monarch:488263 LOC119877881

NCBI Gene:119877881 LOC119877881

NCBI Gene:488263 LOC119877881

UCSC:J9PB22 LOC119877881

Reference Transcript

Other Identifiers

106558262

106558266

115945163

115945196

115945198

119867688

119867704

119877878

119877879

119877881

488263

611519

CfaAffx.251.1.S1_s_at

CfaAffx.945.1.S1_s_at

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0010467

GO:0030527

GO:0032991

GO:0040029

GO:0046982

GO:0065003

Participates

as a candidate of

Me2K10-histone H3 [nucleoplasm] (Canis familiaris)

as a member of

Histone H3 dimethylated at lysine-9 [nucleoplasm] (Canis familiaris)

Other forms of this molecule

LOC119877881 [nucleoplasm]

phospho-LOC119877881 [nucleoplasm]

LOC119877881 [nucleoplasm]

LOC119877881 [extracellular region]

LOC119877881 [nucleoplasm]

phospho-LOC119877881 [nucleoplasm]

LOC119877881 [nucleoplasm]

LOC119877881 [cytosol]

Inferred From

Me2K10-HIST1H3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

RefSeq

XP_005640158.1, XP_038440360.1

ENSEMBL

ENSCAFT00845044837, ENSCAFG00845025410, ENSCAFT00845044925, ENSCAFT00845046307, ENSCAFT00845046147, ENSCAFG00845026258, ENSCAFT00845045048, ENSCAFG00845025523, ENSCAFP00845022002, ENSCAFP00845022331, ENSCAFP00845022267, ENSCAFG00845015682, ENSCAFT00845028387, ENSCAFP00845035310, ENSCAFP00845036234, ENSCAFP00845035137, ENSCAFG00845015962, ENSCAFT00845027953, ENSCAFP00845035205, ENSCAFG00845026157, ENSCAFT00845028301, ENSCAFG00845015914, ENSCAFG00845025460, ENSCAFP00845036367