Reactome | CHRM2 [plasma membrane]

CHRM2 [plasma membrane]

Stable Identifier

R-CFA-390654

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CHRM2, A0A8I3RUS6

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Amine ligand-binding receptors (Canis familiaris)
        
        Muscarinic acetylcholine receptors (Canis familiaris)
        
        CHRM2 binds CHRM2 antagonists (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        CHRM2:CHRM2 antagonists [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        CHRM2,4 bind acetylcholine (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM2,CHRM4 [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - ARRB bind GPCRs (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        CHRM2 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RUS6

Gene Names

CHRM2

Reference Genes

ENSEMBL:ENSCAFG00845008775.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008775.1 CHRM2

Other Identifiers

403858

Cfa.3717.1.A1_s_at

CfaAffx.5974.1.S1_at

GO:0003013

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0007213

GO:0008016

GO:0009615

GO:0016020

GO:0016907

GO:0023052

GO:0030054

GO:0045202

GO:0045211

GO:0060089

GO:0097060

GO:0098793

GO:0098981

GO:0099171

GO:1990763

Participates

as a member of

as an input of

CHRM2 binds CHRM2 antagonists (Canis familiaris)

as a component of

CHRM2:CHRM2 antagonists [plasma membrane] (Canis familiaris)

Other forms of this molecule

CHRM2 [clathrin-coated endocytic vesicle membrane]

Inferred From

CHRM2 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000181072

Ensembl

ENSCAFP00845011984, ENSCAFT00845015430, ENSCAFG00845008775

Cite Us!