Reactome | CHRM2 [clathrin-coated endocytic vesicle membrane]

CHRM2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CFA-8869085

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

CHRM2, A0A8I3RUS6

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CHRM2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RUS6

Gene Names

CHRM2

Reference Genes

ENSEMBL:ENSCAFG00845008775.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008775.1 CHRM2

Other Identifiers

403858

Cfa.3717.1.A1_s_at

CfaAffx.5974.1.S1_at

GO:0003013

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0007213

GO:0008016

GO:0009615

GO:0016020

GO:0016907

GO:0023052

GO:0030054

GO:0045202

GO:0045211

GO:0060089

GO:0097060

GO:0098793

GO:0098981

GO:0099171

GO:1990763

Participates

as a member of

ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

Other forms of this molecule

CHRM2 [plasma membrane]

Inferred From

CHRM2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000181072

Ensembl

ENSCAFT00845015430, ENSCAFG00845008775, ENSCAFP00845011984

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