Reactome | AVP [extracellular region]

AVP [extracellular region]

Stable Identifier

R-CFA-388474

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

AVP(20-28), A0A8I3NZX3

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - ADBRK1,2 phosphorylate AVPR2 (Canis familiaris)
        
        AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - ARRB bind GPCRs (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        ARRB-binding GPCRs [plasma membrane] (Canis familiaris)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Canis familiaris)
        
        AVP [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NZX3

Gene Names

AVP

Reference Genes

BioGPS Gene:403579 AVP

ENSEMBL:ENSCAFG00845015347.1

KEGG:cfa:403579 AVP

Monarch:403579 AVP

NCBI Gene:403579 AVP

UCSC:A0A8I3NZX3 AVP

Reference Transcript

RefSeq:NM_001197149.2 AVP

Other Identifiers

403579

Cfa.96.1.S1_s_at

CfaAffx.10606.1.S1_s_at

GO:0003013

GO:0003824

GO:0004672

GO:0005179

GO:0005184

GO:0005185

GO:0005576

GO:0005615

GO:0007189

GO:0010628

GO:0016740

GO:0031894

GO:0035556

GO:0042310

GO:0043066

GO:0046718

GO:0048018

GO:0070295

GO:0097746

GO:0098772

GO:0140096

Participates

as a component of

as a member of

as an input of

Other forms of this molecule

AVP [clathrin-coated endocytic vesicle membrane]

AVP [cytosol]

Inferred From

AVP(20-28) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001184078.2

ENSEMBL

ENSCAFT00845027375, ENSCAFP00845021550, ENSCAFG00845015347

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