Reactome | LOC612779 [nucleoplasm]

LOC612779 [nucleoplasm]

Stable Identifier

R-CFA-212282

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

Me3K-28-H3F3A, A0A8I3RQJ9

Locations in the PathwayBrowser

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Cell-Cell communication (Canis familiaris)

- Cell junction organization (Canis familiaris)
  - Cell-cell junction organization (Canis familiaris)
    - Adherens junctions interactions (Canis familiaris)
      - Regulation of Homotypic Cell-Cell Adhesion (Canis familiaris)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Canis familiaris)
        
        Regulation of CDH1 Expression and Function (Canis familiaris)
        
        Regulation of CDH1 Gene Transcription (Canis familiaris)
        
        Negative Regulation of CDH1 Gene Transcription (Canis familiaris)
        
        PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (Canis familiaris)
        
        PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Canis familiaris)
        
        LOC612779 [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- Epigenetic regulation of gene expression (Canis familiaris)
  - PRC2 methylates histones and DNA (Canis familiaris)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Canis familiaris)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Canis familiaris)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Canis familiaris)
        
        Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Canis familiaris)
        
        LOC612779 [nucleoplasm] (Canis familiaris)
    - PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Canis familiaris)
        
        Chromatin with trimethylated H3K27 [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Canis familiaris)
        
        LOC612779 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RQJ9

Gene Names

LOC612779

Reference Genes

BioGPS Gene:612779 LOC612779

ENSEMBL:ENSCAFG00845002237.1

KEGG:cfa:612779 LOC612779

Monarch:612779 LOC612779

NCBI Gene:612779 LOC612779

UCSC:A0A8I3RQJ9 LOC612779

Reference Transcript

Other Identifiers

612779

CfaAffx.2698.1.S1_s_at

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005694

GO:0030527

GO:0046982

Participates

as a member of

Histone H3 (H3K27me3) [nucleoplasm] (Canis familiaris)

Other forms of this molecule

LOC612779 [nucleoplasm]

phospho-LOC612779 [nucleoplasm]

LOC612779 [nucleoplasm]

phospho-LOC612779 [nucleoplasm]

LOC612779 [nucleoplasm]

LOC612779 [extracellular region]

LOC612779 [nucleoplasm]

Inferred From

Me3K-28-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 28 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

XP_038509994.1, XP_038381864.1, XP_003432554.1

ENSEMBL

ENSCAFT00845003923, ENSCAFG00845002237, ENSCAFP00845003127