Reactome | TRBC1 [plasma membrane]

TRBC1 [plasma membrane]

Stable Identifier

R-CFA-198188

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

A0A8I3PF21

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Canis familiaris)
    - TCR binds microbial lipid-based antigen via CD1 (Canis familiaris)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
    - TCR binds self-lipid-based antigen via CD1 (Canis familiaris)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Canis familiaris)
      - T-cell receptor complex with CD8 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with CD8 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-inhibition by PD-1 (Canis familiaris)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
  - TCR signaling (Canis familiaris)
    - Downstream TCR signaling (Canis familiaris)
      - Change of PKC theta conformation (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
    - Generation of second messenger molecules (Canis familiaris)
      - Phosphorylation of PLC-gamma1 (Canis familiaris)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of SLP-76 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of TBSMs in LAT (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
    - Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
      - Activation of Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Inactivation of LCK by PTPN22 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Inactivation of Lck by Csk (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
    - Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
      - Activation of ZAP-70 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - PTPN22 dephosphorylates ZAP70 (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Phosphorylation of ZAP-70 by Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain beta [plasma membrane] (Canis familiaris)
        
        Homologues of TRBC1 [plasma membrane] (Canis familiaris)
        
        TRBC1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PF21

Reference Genes

ENSEMBL:ENSCAFG00845018779.1

UCSC:A0A8I3PF21

Other Identifiers

CfaAffx.6644.1.S1_s_at

GO:0042101

GO:0042105

Participates

as a member of

Homologues of TRBC1 [plasma membrane] (Canis familiaris)

Inferred From

TRBC1 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFG00845018779, ENSCAFP00845025981, ENSCAFT00845033190

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