Reactome | TRBC1 [plasma membrane]

TRBC1 [plasma membrane]

Stable Identifier

R-HSA-198188

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

T-cell receptor beta chain C region, TCB_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
    - TCR binds self-lipid-based antigen via CD1 (Homo sapiens)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
      - T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with CD8 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
  - TCR signaling (Homo sapiens)
    - Downstream TCR signaling (Homo sapiens)
      - Change of PKC theta conformation (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
    - Generation of second messenger molecules (Homo sapiens)
      - Phosphorylation of PLC-gamma1 (Homo sapiens)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of SLP-76 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of TBSMs in LAT (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
    - Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
      - Activation of Lck (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Inactivation of LCK by PTPN22 (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Inactivation of Lck by Csk (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
    - Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
      - Activation of ZAP-70 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - PTPN22 dephosphorylates ZAP70 (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Phosphorylation of ZAP-70 by Lck (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        T-cell receptor [plasma membrane] (Homo sapiens)
        
        TCR chain beta [plasma membrane] (Homo sapiens)
        
        TRBC1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01850 TRBC1

Gene Names

TRBC1

Chain

chain:1-176

Reference Genes

HGNC:12156 TRBC1

OMIM:186930 TRBC1

UCSC:P01850 TRBC1

Participates

as a member of

TCR chain beta [plasma membrane] (Homo sapiens)

Inferred To

ENSRNOG00000070909 [plasma membrane] (Rattus norvegicus)

TRBC1 [plasma membrane] (Canis familiaris)

TRBC1 [plasma membrane] (Sus scrofa)

Cross References

OpenTargets

ENSG00000211751

HPA

ENSG00000211751-TRBC1

PRO

P01850

Pharos - Targets

P01850

GlyGen

P01850

PDB

4G8E, 4G8F, 2F53, 2ESV, 3FFC, 2VLK, 2PYF, 4PRH, 4JFH, 4X6C, 2VLM, 3KPS, 4JRX, 4ZDH, 7RYL, 4GG6, 4JFE, 2P5W, 3HE6, 4L9L, 4PRI, 1AO7, 3HG1, 3ARE, 4NQE, 3D3V, 3ARG, 4NQC, 2BNU, 4JFF, 2BNQ, 4OZG, 2BNR, 4L4V, 1FYT, 2XNA, 4MJI, 7T2C, 7T2B, 4MNQ, 4OZI, 1J8H, 3DX9, 1OGA, 3ARB, 4LCC, 2F54, 2VLR, 3TN0, 4X6B, 2VLJ, 2PYE, 7RYO, 1YMM, 7RYN, 2IAN, 3KPR, 2IAM, 2IAL, 4X6D, 2GJ6, 1ZGL, 1MI5, 2AXH, 4JFD, 3ARF, 4JRY, 2PO6, 3ARD, 4IIQ, 4PRP, 1KTK, 4L4T, 7RYM, 2NTS, 4NQD, 4GG8, 2AK4, 2CDG, 4OZH, 1KGC, 2NW2, 3DXA, 2CDE, 2NX5, 2CDF, 4OZF, 3O4L, 2XN9, 4LCW, 2P5E, 3D39, 7T2D, 4P46

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2

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