Reactome | HSP90AA1 [cytosol]

HSP90AA1 [cytosol]

Stable Identifier

R-CFA-192864

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

HSP90AA1, A0A8I3MR78

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by ERBB2 (Canis familiaris)
    - Downregulation of ERBB2 signaling (Canis familiaris)
      - CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)
        
        ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)
        
        ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
    - Drug-mediated inhibition of ERBB2 signaling (Canis familiaris)
      - ERBB2 binds TKIs (Canis familiaris)
        
        ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
    - ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Canis familiaris)
      - ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
    - Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
      - ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
        
        HSP90 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - CRK binds BCAR1 and or PXN (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - DOCK180:ELMO binds CRK (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - HSP90AA1 binds p-6Y-VEGFR2 (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - PXN binds p-6Y,S732-PTK2 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
      - p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RHOBTB GTPase Cycle (Canis familiaris)
        
        RHOBTB2 GTPase cycle (Canis familiaris)
        
        RHOBTB2 binds GTP (Canis familiaris)
        
        HSP90:CDC37 [cytosol] (Canis familiaris)
        
        HSP90 dimer [cytosol] (Canis familiaris)
        
        HSP90AA1,HSP90AB1 [cytosol] (Canis familiaris)
        
        HSP90AA1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MR78

Gene Names

HSP90AA1

Reference Genes

ENSEMBL:ENSCAFG00845005495.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845005495.1 HSP90AA1

Other Identifiers

480438

Cfa.293.1.S1_s_at

Cfa.293.1.S2_at

CfaAffx.27629.1.S1_s_at

GO:0000166

GO:0001934

GO:0002218

GO:0002230

GO:0002376

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006457

GO:0006886

GO:0007004

GO:0007005

GO:0008092

GO:0012501

GO:0016787

GO:0016887

GO:0030163

GO:0030235

GO:0030911

GO:0031396

GO:0031410

GO:0031625

GO:0032200

GO:0032273

GO:0032728

GO:0032880

GO:0032991

GO:0034605

GO:0036211

GO:0042470

GO:0042802

GO:0042803

GO:0042826

GO:0042981

GO:0043025

GO:0043226

GO:0044183

GO:0044294

GO:0044295

GO:0045040

GO:0045429

GO:0045732

GO:0048156

GO:0048471

GO:0050821

GO:0051020

GO:0051082

GO:0051131

GO:0061024

GO:0065003

GO:0070182

GO:0097110

GO:0097718

GO:0098542

GO:0098586

GO:0098772

GO:0140657

GO:0140662

GO:1905323

GO:1990782

Participates

as a component of

as an input of

HSP90AA1 binds p-6Y-VEGFR2 (Canis familiaris)

as a member of

HSP90AA1,HSP90AB1 [cytosol] (Canis familiaris)

Other forms of this molecule

HSP90AA1 [secretory granule lumen]

HSP90AA1 [ficolin-1-rich granule lumen]

HSP90AA1 [extracellular region]

HSP90AA1 [plasma membrane]

HSP90AA1 [nucleoplasm]

Inferred From

HSP90AA1 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000080824

Ensembl

ENSCAFT00845009784, ENSCAFP00845007648, ENSCAFG00845005495

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