Reactome | STAM2 [cytosol]

STAM2 [cytosol]

Stable Identifier

R-CFA-182965

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

STAM2, A0A8I3NGD3

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by EGFR (Canis familiaris)
    - EGFR downregulation (Canis familiaris)
      - CBL-mediated ubiquitination of CIN85 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - EGFR non-clathrin mediated endocytosis (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - EGFR phosphorylates EPS15 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PTPN3 dephosphorylates EPS15 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - Sprouty sequesters CBL away from active EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
  - Signaling by MET (Canis familiaris)
    - Negative regulation of MET activity (Canis familiaris)
      - EPS15 and HGS bind ubiquitinated MET (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Canis familiaris)
        
        EPS15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RHOU GTPase cycle (Canis familiaris)
        
        RHOU binds effectors at the plasma membrane (Canis familiaris)
        
        RHOU effectors [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Canis familiaris)
        
        RHOU effectors [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - Epsin family proteins bind ubiquitinated cargo (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        p-Eps15:HGS:STAM [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
  - Endosomal Sorting Complex Required For Transport (ESCRT) (Canis familiaris)
    - Cargo Recognition And Sorting (Canis familiaris)
      - ESCRT-0 [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)
      - ESCRT-0/Cargo Complex [endosome membrane] (Canis familiaris)
        
        ESCRT-0 [cytosol] (Canis familiaris)
        
        STAM [cytosol] (Canis familiaris)
        
        STAM2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NGD3

Gene Names

STAM2

Reference Genes

BioGPS Gene:119864504 STAM2

ENSEMBL:ENSCAFG00845010553.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845010553.1 STAM2

Monarch:119864504 STAM2

NCBI Gene:119864504 STAM2

Reference Transcript

RefSeq:XM_014121525.1 STAM2

Other Identifiers

119864504

Cfa.13041.1.A1_s_at

CfaAffx.9649.1.S1_s_at

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0008289

GO:0015031

GO:0031410

GO:0031901

GO:0035091

GO:0043130

GO:0043226

GO:0043231

Participates

as a candidate of

RHOU effectors [cytosol] (Canis familiaris)

as a component of

USP8:STAM2:HGS [cytosol] (Canis familiaris)

as a member of

STAM [cytosol] (Canis familiaris)

Other forms of this molecule

STAM2 [cytosol]

Inferred From

STAM2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013977000.1

OpenTargets

ENSG00000115145

Ensembl

ENSCAFT00845018612, ENSCAFG00845010553, ENSCAFP00845014519

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