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What is Reactome ?
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phospho-SRC [plasma membrane]
Stable Identifier
R-CFA-1810408
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
MyrG-p-Y419-SRC, A0A8I3SBF9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Activation of Cdc42 (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Activation of Rac1 (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
DCC interacting NCK-1 (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Phosphorylation of DCC by Fyn (Canis familiaris)
NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
RhoGTPase GEF's recruited to DCC (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX3 (Canis familiaris)
Regulation of RUNX3 expression and activity (Canis familiaris)
RUNX3 binds SRC (Canis familiaris)
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
RUNX3 translocates to the nucleus (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
SRC phosphorylates RUNX3 (Canis familiaris)
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAF activation (Canis familiaris)
Phosphorylation of RAF (Canis familiaris)
RAF activating kinases [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
ESR-associated SRC autophosphorylates (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
PI3K binds membrane-associated estrogen receptors (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
PTK2 is recruited to methylated ESR1 (Canis familiaris)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
SRC family kinases phosphorylate ERBB2 (Canis familiaris)
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Signaling by ERBB4 (Canis familiaris)
Downregulation of ERBB4 signaling (Canis familiaris)
ERBB4s80 binds to SRC (Canis familiaris)
ERBB4s80:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Nuclear signaling by ERBB4 (Canis familiaris)
Translocation of ERBB4s80 to the nucleus (Canis familiaris)
ERBB4s80:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Signaling by MET (Canis familiaris)
MET promotes cell motility (Canis familiaris)
MET activates PTK2 signaling (Canis familiaris)
MET phosphorylates PTK2 (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
SRC phosphorylates PTK2 (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
p-Y397-PTK2 binds SRC (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK3 (TRKC) (Canis familiaris)
Activated NTRK3 signals through PI3K (Canis familiaris)
Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
Activation of Src (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-SRC [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3SBF9
Gene Names
SRC
Reference Genes
BioGPS Gene:485864 SRC
ENSEMBL:ENSCAFG00845028314.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028314.1 SRC
KEGG Gene (Canis lupus familiaris):485864 SRC
Monarch:485864 SRC
NCBI Gene:485864 SRC
Reference Transcript
RefSeq:XM_005635037.2 SRC
RefSeq:XM_014107153.1 SRC
RefSeq:XM_005635038.2 SRC
Other Identifiers
485864
Cfa.11456.1.A1_at
CfaAffx.13882.1.S1_at
GO:0000166
GO:0002102
GO:0002376
GO:0003013
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005743
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005901
GO:0005925
GO:0006468
GO:0007010
GO:0007155
GO:0007179
GO:0007229
GO:0010632
GO:0010634
GO:0010954
GO:0012501
GO:0016004
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0019899
GO:0019904
GO:0020037
GO:0022407
GO:0022414
GO:0023052
GO:0030054
GO:0030154
GO:0030900
GO:0031333
GO:0031410
GO:0031648
GO:0032200
GO:0032211
GO:0032587
GO:0033146
GO:0034139
GO:0034330
GO:0034446
GO:0034614
GO:0035306
GO:0035332
GO:0035556
GO:0036035
GO:0036120
GO:0036211
GO:0038166
GO:0042169
GO:0042476
GO:0043066
GO:0043149
GO:0043226
GO:0043274
GO:0044325
GO:0045453
GO:0045747
GO:0046875
GO:0048041
GO:0048471
GO:0048477
GO:0048856
GO:0048870
GO:0050731
GO:0051057
GO:0051219
GO:0051604
GO:0051897
GO:0051902
GO:0060065
GO:0060444
GO:0060491
GO:0060576
GO:0065003
GO:0070102
GO:0070301
GO:0070374
GO:0070555
GO:0070700
GO:0071253
GO:0071375
GO:0071498
GO:0071560
GO:0071803
GO:0086091
GO:0090263
GO:0097110
GO:0098542
GO:0098772
GO:0140096
GO:1900182
GO:1904263
GO:2000394
GO:2000588
GO:2000641
GO:2000811
GO:2001237
GO:2001243
GO:2001286
Participates
as a component of
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Canis familiaris)
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
ERBB4s80:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Canis familiaris)
as an output of
SRC phosphorylates RUNX3 (Canis familiaris)
as an input of
RUNX3 binds SRC (Canis familiaris)
ERBB4s80 binds to SRC (Canis familiaris)
p-Y397-PTK2 binds SRC (Canis familiaris)
as a member of
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Canis familiaris)
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Canis familiaris)
as a candidate of
RAF activating kinases [plasma membrane] (Canis familiaris)
This entity regulates
Negatively
RUNX3 translocates to the nucleus
(Canis familiaris)
Other forms of this molecule
SRC [cytosol]
phospho-SRC [cytosol]
SRC [plasma membrane]
phospho-SRC [plasma membrane]
phospho-SRC [cytosol]
phospho-SRC [plasma membrane]
SRC [plasma membrane]
SRC [cytosol]
Inferred From
MyrG-p-Y419-SRC [plasma membrane]
(Homo sapiens)
Modified Residues
Name
N-myristoylglycine at 2 (in Homo sapiens)
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Name
O4'-phospho-L-tyrosine at 419 (in Homo sapiens)
Coordinate
419
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_013962628.1
,
XP_005635094.1
,
XP_005635095.1
OpenTargets
ENSG00000197122
Ensembl
ENSCAFG00845028314
,
ENSCAFT00845050058
,
ENSCAFP00845039250
© 2024
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