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phospho-CHUK [cytosol]
Stable Identifier
R-CFA-177667
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S176,S180-CHUK, A0A8I3P499
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-CHUK [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P499
Gene Names
CHUK
Reference Genes
BioGPS Gene:477796 CHUK
ENSEMBL:ENSCAFG00845016257.1
Monarch:477796 CHUK
NCBI Gene:477796 CHUK
UCSC:A0A8I3P499 CHUK
Reference Transcript
RefSeq:XM_534990.7 CHUK
RefSeq:XM_038440265.1 CHUK
RefSeq:XM_038578512.1 CHUK
Other Identifiers
477796
CfaAffx.15073.1.S1_at
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006468
GO:0007249
GO:0008384
GO:0008385
GO:0016301
GO:0016740
GO:0032727
GO:0033209
GO:0034142
GO:0038061
GO:0042803
GO:0043123
GO:0045944
GO:0046982
GO:0071356
GO:0097110
GO:0098586
GO:0140096
GO:1990459
Participates
as a component of
p-S176,S180-IKKA dimer [cytosol] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-CHUK [cytosol]
phospho-CHUK [cytosol]
CHUK [cytosol]
Inferred From
p-S176,S180-CHUK [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 176 (in Homo sapiens)
Coordinate
176
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 180 (in Homo sapiens)
Coordinate
180
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_534990.2
,
XP_038434440.1
,
XP_038296193.1
ENSEMBL
ENSCAFT00845028900
,
ENSCAFP00845022741
,
ENSCAFG00845016257
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