Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CHUK [cytosol]
Stable Identifier
R-CFA-168104
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CHUK, A0A8I3P499
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Activated IKK phosphorylates I-kappaB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Activation of IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
PKR-mediated signaling (Canis familiaris)
IKK complex is activated by PKR (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NEMO binds polyubiquitinated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
IKKA dimer [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
IKKA dimer [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
Phosphorylation of IKK-beta by TAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
IKK complex recruitment mediated by RIP1 (Canis familiaris)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
LRRC14 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P499
Gene Names
CHUK
Reference Genes
BioGPS Gene:477796 CHUK
ENSEMBL:ENSCAFG00845016257.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016257.1 CHUK
Monarch:477796 CHUK
NCBI Gene:477796 CHUK
Reference Transcript
RefSeq:XM_534990.5 CHUK
Other Identifiers
477796
CfaAffx.15073.1.S1_at
GO:0002376
GO:0003824
GO:0004672
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0007249
GO:0008384
GO:0016740
GO:0023052
GO:0032727
GO:0034142
GO:0034614
GO:0036211
GO:0038061
GO:0042803
GO:0043123
GO:0043226
GO:0045893
GO:0045944
GO:0046982
GO:0071276
GO:0071356
GO:0097110
GO:0098542
GO:0098586
GO:0140096
GO:1990459
Participates
as a component of
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKKA dimer [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:LRRC14 [cytosol] (Canis familiaris)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
as an input of
LRRC14 binds IKBKB and CHUK (Canis familiaris)
NLRC5 binds IKBKB and CHUK (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
Other forms of this molecule
phospho-CHUK [cytosol]
phospho-CHUK [cytosol]
Inferred From
CHUK [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_534990.2
OpenTargets
ENSG00000213341
Ensembl
ENSCAFG00845016257
,
ENSCAFP00845022741
,
ENSCAFT00845028900
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text