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CDC23 [cytosol]
Stable Identifier
R-CFA-174137
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CDC23, A0A8I3PAB5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
Mitotic Spindle Checkpoint (Canis familiaris)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Canis familiaris)
Inactivation of APC/C via direct inhibition of the APC/C complex (Canis familiaris)
Binding of the MCC complex to the APC/C complex (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Separation of Sister Chromatids (Canis familiaris)
Association of Securin with Cdc20:APC/C complex (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)
CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Canis familiaris)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Canis familiaris)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of Cyclin B (Canis familiaris)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Degradation of multiubiquitinated Cyclin B (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Canis familiaris)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Canis familiaris)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
APC/C:Cdc20 mediated degradation of Securin (Canis familiaris)
Association of Securin with Cdc20:APC/C complex (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)
CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Canis familiaris)
APC-Cdc20 mediated degradation of Nek2A (Canis familiaris)
Association of Nek2A with MCC:APC/C (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Degradation of multiubiquitinated Nek2A (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Multiubiquitination of Nek2A (Canis familiaris)
Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Canis familiaris)
Association of Cyclin A with the APC/C (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Degradation multiubiquitinated Cyclin A (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Canis familiaris)
Association of Cdh1 with the APC/C (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Dissociation of Cdc20 from APC/C complex (Canis familiaris)
CDC20:p-APC/C [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Regulation of APC/C activators between G1/S and early anaphase (Canis familiaris)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Canis familiaris)
Inactivation of APC/C via direct inhibition of the APC/C complex (Canis familiaris)
Binding of the MCC complex to the APC/C complex (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
DNA Replication (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
APC/C E3 ligase complex [cytosol] (Canis familiaris)
CDC23 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PAB5
Gene Names
CDC23
Reference Genes
ENSEMBL:ENSCAFG00845019698.1
UCSC:A0A8I3PAB5 CDC23
Other Identifiers
481526
481527
Cfa.12776.1.A1_at
Cfa.20943.1.S1_s_at
CfaAffx.2704.1.S1_at
CfaAffx.2710.1.S1_s_at
GO:0004888
GO:0005515
GO:0005680
GO:0005886
GO:0007169
GO:0007399
GO:0016020
GO:0038023
GO:0048856
GO:0051301
GO:0098552
Participates
as a component of
APC/C E3 ligase complex [cytosol] (Canis familiaris)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
Other forms of this molecule
CDC23 [nucleoplasm]
Inferred From
CDC23 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845027211
,
ENSCAFG00845019698
,
ENSCAFT00845034747
© 2026
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