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SMURF2 [cytosol]
Stable Identifier
R-CFA-173537
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SMURF2, A0A8I3PG60
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Canis familiaris)
SMAD7:SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Canis familiaris)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Canis familiaris)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
ub-PTCH1:SMURF [ciliary membrane] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by BMP (Canis familiaris)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Canis familiaris)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Canis familiaris)
I-SMAD:SMURF [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
I-SMAD:SMURF [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
SMURF2 binds SMAD2 (Canis familiaris)
SMAD2:SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF2 ubiquitinates SMAD2 (Canis familiaris)
SMAD2:SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
PCP/CE pathway (Canis familiaris)
Asymmetric localization of PCP proteins (Canis familiaris)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Canis familiaris)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Degradation of AXIN (Canis familiaris)
AXIN is ubiquitinated by SMURF2 (Canis familiaris)
AXIN:SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
ub-AXIN:SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF2 binds AXIN (Canis familiaris)
AXIN:SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
ub-AXIN:SMURF2 [cytosol] (Canis familiaris)
SMURF2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PG60
Gene Names
SMURF2
Reference Genes
BioGPS Gene:480470 SMURF2
ENSEMBL:ENSCAFG00845023989.1
KEGG:cfa:480470 SMURF2
Monarch:480470 SMURF2
NCBI Gene:480470 SMURF2
UCSC:A0A8I3PG60 SMURF2
Reference Transcript
RefSeq:XM_038546847.1 SMURF2
RefSeq:XM_038627783.1 SMURF2
RefSeq:XM_038676037.1 SMURF2
Other Identifiers
480470
CfaAffx.18144.1.S1_s_at
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006511
GO:0016020
GO:0016567
GO:0016740
GO:0045121
GO:0061630
GO:0140096
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Canis familiaris)
AXIN:SMURF2 [cytosol] (Canis familiaris)
ub-AXIN:SMURF2 [cytosol] (Canis familiaris)
SMAD7:SMURF2 [cytosol] (Canis familiaris)
SMAD2:SMURF2 [cytosol] (Canis familiaris)
as an output of
Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)
SMURF2 ubiquitinates SMAD2 (Canis familiaris)
as an input of
SMURF2 binds AXIN (Canis familiaris)
SMURF2 binds SMAD2 (Canis familiaris)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SMURF [cytosol] (Canis familiaris)
Other forms of this molecule
SMURF2 [nucleoplasm]
Inferred From
SMURF2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_038483711.1
,
XP_038402775.1
,
XP_038531965.1
ENSEMBL
ENSCAFT00845042371
,
ENSCAFP00845033218
,
ENSCAFG00845023989
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