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p-T,Y MAPK dimers [cytosol]
Stable Identifier
R-CFA-1268261
Type
Set [DefinedSet]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-ERK dimer
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
Constitutive phosphorylation by pERK1/2 (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Developmental Biology (Canis familiaris)
MITF-M-regulated melanocyte development (Canis familiaris)
Transcriptional and post-translational regulation of MITF-M expression and activity (Canis familiaris)
MAPK-dependent phosphorylation of KARS (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by NODAL (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Interferon gamma signaling (Canis familiaris)
IFNG signaling activates MAPKs (Canis familiaris)
JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Apoptotic factor-mediated response (Canis familiaris)
Cytochrome c-mediated apoptotic response (Canis familiaris)
Formation of apoptosome (Canis familiaris)
Regulation of the apoptosome activity (Canis familiaris)
CASP9 is phosphorylated at T412 (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Canis familiaris)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
MAPKs phosphorylate PP2A (Canis familiaris)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
PEA15 binds MAPK monomers and dimers (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Phosphorylated MAPKs translocate into the nucleus (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPKs dimerize (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Negative feedback regulation of MAPK pathway (Canis familiaris)
Activated MAPK phosphorylates RAF1 (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Activated MAPKs phosphorylate BRAF (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
PEA15 binds MAPK monomers and dimers (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Phosphorylated MAPKs translocate into the nucleus (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Canis familiaris)
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPKs dimerize (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Signalling to ERKs (Canis familiaris)
Prolonged ERK activation events (Canis familiaris)
Frs2-mediated activation (Canis familiaris)
p-T,Y MAPK dimers translocate to nucleus (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
p-T,Y MAPKs dimerize (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by Activin (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-T,Y MAPK dimers [cytosol] (Canis familiaris)
Participants
members
p-T202, Y204 MAPK3 dimer [cytosol]
(Canis familiaris)
p-T185,Y187 MAPK1 dimer [cytosol]
(Canis familiaris)
Participates
as an input of
p-T,Y MAPK dimers translocate to nucleus (Canis familiaris)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Canis familiaris)
as an output of
MAPKs phosphorylate PP2A (Canis familiaris)
JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)
p-T,Y MAPKs dimerize (Canis familiaris)
as a component of
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Canis familiaris)
as a member of
p-T,Y MAPK monomers and dimers [cytosol] (Canis familiaris)
This entity regulates
Negatively
The SMAD2/3:SMAD4 complex transfers to the nucleus
(Canis familiaris)
Positively
SPRY2 is serine phosphorylated in response to MAPK activation
(Canis familiaris)
Inferred From
p-T,Y MAPK dimers [cytosol]
(Homo sapiens)
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