Reactome | EGLN3 [cytosol]

EGLN3 [cytosol]

Stable Identifier

R-CFA-1234115

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

EGLN3, A0A8I3ND68

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular response to hypoxia (Canis familiaris)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
      - Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
        
        VBC complex (with or without LIMD1) [cytosol] (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Canis familiaris)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
        
        PHD2,3 [cytosol] (Canis familiaris)
        
        EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
        
        EGLN3 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3ND68

Gene Names

EGLN3

Reference Genes

BioGPS Gene:480286 EGLN3

ENSEMBL:ENSCAFG00845012583.1

KEGG:cfa:480286 EGLN3

Monarch:480286 EGLN3

NCBI Gene:480286 EGLN3

UCSC:A0A8I3ND68 EGLN3

Reference Transcript

Other Identifiers

480286

Cfa.17230.1.S1_s_at

GO:0003824

GO:0005506

GO:0005634

GO:0005737

GO:0005829

GO:0016491

GO:0016705

GO:0016706

GO:0031418

GO:0031545

GO:0046872

GO:0051213

GO:0140096

Participates

as a component of

EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)

Other forms of this molecule

EGLN3 [nucleoplasm]

Inferred From

EGLN3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_537408.3, XP_038529327.1, XP_038400396.1

ENSEMBL

ENSCAFT00845022410, ENSCAFP00845017606, ENSCAFG00845012583